Oncogenic mutations are abundant in the tissues of healthy individuals, but rarely form
tumours,–. Yet, the underlying protection mechanisms are largely unknown. To resolve …

When in equilibrium, thermal forces agitate molecules, which then diffuse, collide and bind
to form materials. However, the space of accessible structures in which micron-scale …

Interactions between tumour cells and the surrounding microenvironment contribute to
tumour progression, metastasis and recurrence,–. Although mosaic analyses in Drosophila …

Solid malignancies have been speculated to depend on cancer stem cells (CSCs) for
expansion and relapse after therapy. Here we report on quantitative analyses of lineage …

How stem cells self-organize to form structured tissues is an unsolved problem. Intestinal
organoids offer a model of self-organization as they generate stem cell zones (SCZs) of …

Morphogenesis is extremely diverse, but its systematic quantification to determine the
physical mechanisms that produce different phenotypes is possible by quantifying the …

Branching morphogenesis is a prototypical example of complex three-dimensional organ
sculpting, required in multiple developmental settings to maximize the area of exchange …

During mouse embryogenesis, progenitors within the liver known as hepatoblasts give rise
to adult hepatocytes and cholangiocytes. Hepatoblasts, which are specified at E8. 5-E9. 0 …

Genetic mosaicism can manifest as spatially variable phenotypes that vary from site to site
within an organism. Here, we use imaging-based phenomics to quantitate phenotypes at …

The cellular basis and extent of neural stem cell (NSC) self-renewal in adult vertebrates, and
their heterogeneity, remain controversial. To explore the functional behavior and dynamics …