DNA lesions pose a major obstacle during gene transcription by RNA polymerase II
(RNAPII) enzymes. The transcription-coupled DNA repair (TCR) pathway eliminates such …

One major role of the eukaryotic peptidic post-translational modifier SUMO in the cell is
transcriptional control. This occurs via modification of virtually all classes of transcriptional …

During transcription-coupled DNA repair (TCR), RNA polymerase II (Pol II) transitions from a
transcriptionally active state to an arrested state that allows for removal of DNA lesions. This …

The SUMO protease SENP6 maintains genomic stability, but mechanistic understanding of
this process remains limited. We find that SENP6 deconjugates SUMO2/3 polymers on a …

Cockayne syndrome (CS) is a segmental premature aging syndrome caused primarily by
defects in the CSA or CSB genes. In addition to premature aging, CS patients typically …

Transcription-blocking DNA lesions (TBLs) in genomic DNA are triggered by a wide variety
of DNA-damaging agents. Such lesions cause stalling of elongating RNA polymerase II …

Ultraviolet (UV) light is a natural genotoxic agent leading to the formation of photolesions
endangering the genomic integrity and thereby the survival of living organisms. To prevent …

Transcription–blocking lesions are specifically targeted by transcription-coupled nucleotide
excision repair (TC-NER), which prevents DNA damage-induced cellular toxicity and …

Transcription-blocking lesions (TBLs) stall elongating RNA polymerase II (Pol II), which then
initiates transcription-coupled repair (TCR) to remove TBLs and allow transcription recovery …

Lesions in genes that result in RNA polymerase II (RNAPII) stalling or arrest are particularly
toxic as they are a focal point of genome instability and potently block further transcription of …