The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian
cells and serves to regulate a multitude of physiological processes has continued to …

Nitric oxide (NO) is a key player in both the development and suppression of tumourigenesis
depending on the source and concentration of NO. In this review, we discuss the …

Akt kinase, a member of AGC kinases, is important in many cellular functions including
proliferation, migration, cell growth and metabolism. There are three known Akt isoforms …

Although the pathobiology of atherosclerosis is a complex multifactorial process, blood flow-
induced shear stress has emerged as an essential feature of atherogenesis. This fluid drag …

Akt is a serine/threonine protein kinase that is activated by a number of growth factors and
cytokines in a phosphatidylinositol-3 kinase–dependent manner. Although antiapoptotic …

It has long been known that endothelial Ca2+ signals drive angiogenesis by recruiting
multiple Ca2+-sensitive decoders in response to pro-angiogenic cues, such as vascular …

Endothelial NOS (eNOS), and its product NO, are vital components of the control of
vasomotor function and cardiovascular homeostasis. In the present review, we will take a …

The endothelium, by releasing nitric oxide (NO), promotes vasodilation and inhibits
inflammation, thrombosis, and vascular smooth muscle cell proliferation. These biological …

Nitric oxide production in response to flow-dependent shear forces applied on the surface of
endothelial cells is a fundamental mechanism of regulation of vascular tone, peripheral …

Nitric oxide (NO) is produced from virtually all cell types composing the myocardium and
regulates cardiac function through both vascular-dependent and-independent effects. The …