Psychedelics in psychiatry: neuroplastic, immunomodulatory, and neurotransmitter mechanisms

A Inserra, D De Gregorio, G Gobbi - Pharmacological Reviews, 2021 - ASPET
Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

To predict, prevent, and manage post-traumatic stress disorder (PTSD): a review of pathophysiology, treatment, and biomarkers

GI Al Jowf, ZT Ahmed, RA Reijnders, L de Nijs… - International journal of …, 2023 - mdpi.com
Post-traumatic stress disorder (PTSD) can become a chronic and severely disabling
condition resulting in a reduced quality of life and increased economic burden. The disorder …

Transcriptomic organization of the human brain in post-traumatic stress disorder

MJ Girgenti, J Wang, D Ji, DA Cruz, MB Stein… - Nature …, 2021 - nature.com
Despite extensive study of the neurobiological correlates of post-traumatic stress disorder
(PTSD), little is known about its molecular determinants. Here, differential gene expression …

Effects of yoga on the autonomic nervous system, gamma-aminobutyric-acid, and allostasis in epilepsy, depression, and post-traumatic stress disorder

CC Streeter, PL Gerbarg, RB Saper, DA Ciraulo… - Medical hypotheses, 2012 - Elsevier
A theory is proposed to explain the benefits of yoga practices in diverse, frequently comorbid
medical conditions based on the concept that yoga practices reduce allostatic load in stress …

[图书][B] Principles of trauma therapy: A guide to symptoms, evaluation, and treatment (DSM-5 update)

JN Briere, C Scott - 2014 - books.google.com
Thoroughly updated with DSM-5 content throughout, Principles of Trauma Therapy, Second
Edition: DSM-5 Update is both comprehensive in scope and highly practical in application …

Glutamate dysregulation and glutamatergic therapeutics for PTSD: Evidence from human studies

LA Averill, P Purohit, CL Averill, MA Boesl, JH Krystal… - Neuroscience …, 2017 - Elsevier
Posttraumatic stress disorder (PTSD) is a chronic and debilitating psychiatric disorder
afflicting millions of individuals across the world. While the availability of robust …

Prefrontal cortex GABAergic deficits and circuit dysfunction in the pathophysiology and treatment of chronic stress and depression

S Ghosal, BD Hare, RS Duman - Current opinion in behavioral sciences, 2017 - Elsevier
Highlights•Chronic stress causes atrophy and decreased connectivity of excitatory neurons
in PFC.•Stress causes disruption of GABAergic inhibitory neurons in the PFC.•GABA …

Neurobiological mechanisms of stress resilience and implications for the aged population

C Faye, JC McGowan, CA Denny… - Current …, 2018 - ingentaconnect.com
Background: Stress is a common reaction to an environmental adversity, but a dysregulation
of the stress response can lead to psychiatric illnesses such as major depressive disorder …

Systematic Review, Meta-Analysis, and Meta–Regression Analysis of Prospective Studies

GE Smid, TTM Mooren, RC van der Mast… - J Clin …, 2009 - psychiatrist.com
Objective: Prevalence estimates of delayed posttraumatic stress disorder (PTSD) have
varied widely in the literature. This study is the first to establish the prevalence of delayed …

PTSD in women is associated with a block in conversion of progesterone to the GABAergic neurosteroids allopregnanolone and pregnanolone measured in plasma

SL Pineles, YI Nillni, G Pinna, J Irvine, A Webb… - …, 2018 - Elsevier
There is a need to identify new and more effective treatments for posttraumatic stress
disorder (PTSD). Allopregnanolone and its stereoisomer pregnanolone (together termed …