Depression is a serious neurological disorder characterized by strong loss of interest,
possibly leading to suicide. According to the World Health Organization, more than 300 …

Roughly one-third of the human lifetime is spent in sleep, yet the reason for sleep remains
unclear. Understanding the physiologic function of sleep is crucial toward establishing …

Identification of mechanisms which increase deep sleep could lead to novel treatments
which promote the restorative effects of sleep. Here, we show that knockdown of the α3 …

High prevalence and strong associations of chronic disease, poor sleep quality, poor mental
health, and suicidal ideation (SI) have been reported worldwide. However, the underlying …

Excessive arousal has a role in the pathophysiology of major depressive disorder (MDD).
Seltorexant (JNJ-42847922/MIN-202) is a selective antagonist of the human orexin-2 …

Irritability in pediatric samples is associated with higher rates of subsequent suicide-related
outcomes. No study, to date, has evaluated the longitudinal association between irritability …

Suicidality is one of the leading causes of death among young adults in the United States
and represents a significant health problem worldwide. The suicide rate among adolescents …

Maturation is presumably the indispensable component in determining our sleep, 29 yet in
childhood sleep evolves in complex ways. In fact, worldwide normative, age-appropriate …

Sleep disturbances are associated with suicide-related thoughts and behaviors, and the
incidence of sleep concerns and suicide has increased recently in the US. Most published …

Suicide is a leading cause of death worldwide; in the United States it is the tenth leading
cause of death across the lifespan and the second leading cause of death among youth …