Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …

Despite the overwhelming success of vaccines in preventing infectious diseases, there
remain numerous globally devastating diseases without fully protective vaccines, particularly …

Background The discovery of potent and broadly neutralizing antibodies (bNAbs) against
human immunodeficiency virus (HIV) has made passive immunization a potential strategy …

The viscoelastic mucus secretions coating exposed organs such as the lung airways and the
female reproductive tract can trap and quickly eliminate not only foreign pathogens and …

HIV employs multiple means to evade the humoral immune response, particularly the
elicitation of and recognition by broadly neutralizing antibodies (bnAbs). Such antibodies …

Antibodies have been used for more than 100 years in the therapy of infectious diseases,
but a new generation of highly potent and/or broadly cross-reactive human monoclonal …

Combination anti-retroviral therapy (ART) has revolutionized the treatment and prevention of
HIV-1 infection. Taken daily, ART prevents and suppresses the infection. However, ART …

Broadly neutralizing antibodies (bNAbs) against HIV-1 provide both effective pre-exposure
prophylaxis and treatment of HIV-1 infection in murine and nonhuman primate models …

A major goal of HIV-1 vaccine research is the design of immunogens capable of inducing
broadly neutralizing antibodies (bnAbs) that bind to the viral envelope glycoprotein (Env) …

Adjuvants enhance immunity to vaccines and experimental antigens by a variety of
mechanisms. In the past decade, many receptors and signaling pathways in the innate …