Dr Irvine Page proposed the Mosaic Theory of Hypertension in the 1940s advocating that
hypertension is the result of many factors that interact to raise blood pressure and cause end …

Monocytes develop in the bone marrow and represent the primary type of mononuclear
phagocyte found in the blood. They were long thought of as a source for tissue …

Thirty years after the discovery of its production by activated macrophages, our appreciation
of the diverse roles of nitric oxide (NO) continues to grow. Recent findings have not only …

Background Several studies reported a U-shaped association between urinary sodium
excretion and cardiovascular disease events and mortality. Whether these associations vary …

The immune system probably evolved to limit the negative effects exerted by pathogens on
host homeostasis. This defence strategy relies on the concerted action of innate and …

Background: Salt sensitivity of blood pressure is an independent predictor of cardiovascular
morbidity and mortality. The exact mechanism by which salt intake increases blood pressure …

Sodium accumulates in the interstitium and promotes inflammation through poorly defined
mechanisms. We describe a pathway by which sodium enters dendritic cells (DCs) through …

FOXP3+ Tregs are central for the maintenance of self-tolerance and can be defective in
autoimmunity. In multiple sclerosis and type-1 diabetes, dysfunctional self-tolerance is …

A Western lifestyle with high salt consumption can lead to hypertension and cardiovascular
disease. High salt may additionally drive autoimmunity by inducing T helper 17 (TH17) cells …

Hypertension is a global health problem, with> 1.3 billion individuals with high blood
pressure worldwide. In this Review, we present an inflammatory paradigm for hypertension …