Cell-based therapeutics are an emerging modality with the potential to treat many currently
intractable diseases through uniquely powerful modes of action. Despite notable recent …

CRISPR-Cas gene editing has revolutionized experimental molecular biology over the past
decade and holds great promise for the treatment of human genetic diseases. Here we …

Cytosine base editors (CBEs) efficiently generate precise C· G-to-T· A base conversions, but
the activation-induced cytidine deaminase/apolipoprotein B mRNA-editing enzyme catalytic …

Adenine base editors (ABEs) catalyze A-to-G transitions showing broad applications, but
their bystander mutations and off-target editing effects raise safety concerns. Through …

Pristine graphene has been considered one of the most promising materials because of its
excellent physical and chemical properties. However, various defects in graphene produced …

Our ability to edit genomes lags behind our capacity to sequence them, but the growing
understanding of CRISPR biology and its application to genome, epigenome and …

The establishment of CRISPR/Cas9 (clustered regularly interspaced short palindromic
repeats/CRISPR-associated protein 9) technology for eukaryotic gene editing opened up …

Cytosine base editors (CBEs) are great additions to the expanding genome editing toolbox.
To improve C‐to‐T base editing in plants, we first compared seven cytidine deaminases in …

A fundamental challenge in biology is understanding the molecular details of protein
function. How mutations alter protein activity, regulation, and response to drugs is of critical …

Prime editing is a versatile and precise genome editing technique that can directly copy
desired genetic modifications into target DNA sites without the need for donor DNA. This …