Neuropathic pain has been described as the “most terrible of all tortures which a nerve
wound may inflict” and arises as a consequence of nerve injury either of the peripheral or …

Pain is a significant national burden in terms of patient suffering, expenditure and lost
productivity. Understanding pain is fundamental to improving evaluation, treatment and …

Spinal cord stimulation (SCS) may alleviate certain forms of neuropathic pain; its
mechanisms of action are, however, not fully understood. Previous studies have mainly …

Pain, especially when chronic, is a common reason patients seek medical care and it affects
the quality of life and well-being of the patients. Unfortunately, currently available therapies …

Dopaminergic modulation of spinal cord plasticity has long been recognized, but circuits
affected by this system and the precise receptor subtypes involved in this modulation have …

Neuropathic pain represents a challenge to clinicians because it is resistant to commonly
prescribed analgesics due to its largely unknown mechanisms. Here, we investigated a …

The mechanisms that lead to the maintenance of chronic pain states are poorly understood,
but their elucidation could lead to new insights into how pain becomes chronic and how it …

To elucidate the mechanisms of antinociception mediated by the dopaminergic descending
pathway in the spinal cord, we investigated the actions of dopamine (DA) on substantia …

Introduction Although spinal cord stimulation (SCS) is widely used for chronic neuropathic
pain after failed spinal surgery, little is known about the underlying physiological …

Women are more commonly affected than men by restless legs syndrome, and prevalence is
highest amongst those of northern European heritage. The motor manifestations include …