Polymicrobial communities in periodontal disease: Their quasi‐organismal nature and dialogue with the host

G Hajishengallis, RJ Lamont - Periodontology 2000, 2021 - Wiley Online Library
In health, indigenous polymicrobial communities at mucosal surfaces maintain an ecological
balance via both inter‐microbial and host‐microbial interactions that promote their own and …

Roles of Porphyromonas gingivalis and its virulence factors in periodontitis

W Xu, W Zhou, H Wang, S Liang - Advances in protein chemistry and …, 2020 - Elsevier
Periodontitis is an infection-driven inflammatory disease, which is characterized by gingival
inflammation and bone loss. Periodontitis is associated with various systemic diseases …

Klebsiella pneumoniae: going on the offense with a strong defense

MK Paczosa, J Mecsas - Microbiology and molecular biology …, 2016 - Am Soc Microbiol
Klebsiella pneumoniae causes a wide range of infections, including pneumonias, urinary
tract infections, bacteremias, and liver abscesses. Historically, K. pneumoniae has caused …

Periodontitis: from microbial immune subversion to systemic inflammation

G Hajishengallis - Nature reviews immunology, 2015 - nature.com
Periodontitis is a dysbiotic inflammatory disease with an adverse impact on systemic health.
Recent studies have provided insights into the emergence and persistence of dysbiotic oral …

[HTML][HTML] Pathogenesis of Important Virulence Factors of Porphyromonas gingivalis via Toll-Like Receptors

L Jia, N Han, J Du, L Guo, Z Luo, Y Liu - Frontiers in cellular and …, 2019 - frontiersin.org
Periodontitis is a common intraoral infection and is inextricably linked to systemic diseases.
Recently, the regulation between host immunologic response and periodontal pathogens …

Polymicrobial synergy and dysbiosis in inflammatory disease

RJ Lamont, G Hajishengallis - Trends in molecular medicine, 2015 - cell.com
Uncontrolled inflammation of the periodontal area may arise when complex microbial
communities transition from a commensal to a pathogenic entity. Communication among …

Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology

G Hajishengallis, RJ Lamont - Molecular oral microbiology, 2012 - Wiley Online Library
Recent advancements in the periodontal research field are consistent with a new model of
pathogenesis according to which periodontitis is initiated by a synergistic and dysbiotic …

[HTML][HTML] Structure and function: Lipid A modifications in commensals and pathogens

A Steimle, IB Autenrieth, JS Frick - International Journal of Medical …, 2016 - Elsevier
Lipopolysaccharides (LPS) of Gram negative bacteria are one of the most potent stimulators
of the host innate immune system and LPS recognition is essential for the host organism to …

Biosynthesis and export of bacterial lipopolysaccharides

C Whitfield, MS Trent - Annual review of biochemistry, 2014 - annualreviews.org
Lipopolysaccharide molecules represent a unique family of glycolipids based on a highly
conserved lipid moiety known as lipid A. These molecules are produced by most gram …

Influence of saliva on the oral microbiota

PD Marsh, T Do, D Beighton, DA Devine - Periodontology 2000, 2016 - Wiley Online Library
Saliva plays a major role in determining the composition and activity of the oral microbiota,
via a variety of mechanisms. Molecules, mainly from saliva, form a conditioning film on oral …