Prognostic factors and prognostic models for renal cell carcinoma: a literature review
T Klatte, SH Rossi, GD Stewart - World journal of urology, 2018 - Springer
Purpose Following curative treatment for localised renal cell carcinoma (RCC), up to 30% of
patients develop tumour recurrence. Prognostic scores are essential to guide individualised …
patients develop tumour recurrence. Prognostic scores are essential to guide individualised …
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
B Keith, RS Johnson, MC Simon - Nature Reviews Cancer, 2012 - nature.com
Hypoxia-inducible factors (HIFs) are broadly expressed in human cancers, and HIF1α and
HIF2α were previously suspected to promote tumour progression through largely …
HIF2α were previously suspected to promote tumour progression through largely …
Targeting hypoxia-inducible factor-1, for cancer treatment: Recent advances in developing small-molecule inhibitors from natural compounds
Z Ma, X Xiang, S Li, P Xie, Q Gong, BC Goh… - Seminars in cancer …, 2022 - Elsevier
Rapid progress in molecular cancer biology coupled with the discovery of novel oncology
drugs has opened new horizons for cancer target discovery. As one of the crucial signaling …
drugs has opened new horizons for cancer target discovery. As one of the crucial signaling …
HIF-1 in cancer therapy: two decade long story of a transcription factor
Abstract Background: Oxygen (O2) homeostasis is an indispensable requirement of
eukaryotes. O2 concentration in cellular milieu is defined as normoxia (∼ 21% O2) …
eukaryotes. O2 concentration in cellular milieu is defined as normoxia (∼ 21% O2) …
Hypoxia, hypoxia-inducible transcription factors, and renal cancer
Context Renal cancer is a common urologic malignancy, and therapeutic options for
metastatic disease are limited. Most clear cell renal cell carcinomas (ccRCC) are associated …
metastatic disease are limited. Most clear cell renal cell carcinomas (ccRCC) are associated …
Prognostic factors and predictive models in renal cell carcinoma: a contemporary review
M Sun, SF Shariat, C Cheng, V Ficarra, M Murai… - European urology, 2011 - Elsevier
CONTEXT: The natural history of renal cell carcinoma (RCC) is highly unpredictable. Small
renal masses may be accompanied by metastatic disease. Conversely, patients with locally …
renal masses may be accompanied by metastatic disease. Conversely, patients with locally …
Kidney cancer biomarkers and targets for therapeutics: survivin (BIRC5), XIAP, MCL-1, HIF1α, HIF2α, NRF2, MDM2, MDM4, p53, KRAS and AKT in renal cell …
The incidence of renal cell carcinoma (RCC) is increasing worldwide with an approximate
20% mortality rate. The challenge in RCC is the therapy-resistance. Cancer resistance to …
20% mortality rate. The challenge in RCC is the therapy-resistance. Cancer resistance to …
The role of the mammalian target of rapamycin (mTOR) in renal disease
W Lieberthal, JS Levine - Journal of the American Society of …, 2009 - journals.lww.com
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that plays a pivotal
role in mediating cell size and mass, proliferation, and survival. mTOR has also emerged as …
role in mediating cell size and mass, proliferation, and survival. mTOR has also emerged as …
TWIST activation by hypoxia inducible factor-1 (HIF-1): implications in metastasis and development
MH Yang, KJ Wu - Cell cycle, 2008 - Taylor & Francis
Hypoxia is a microenvironmental factor which plays a critical role in development and tumor
progression. The hypoxic response is mainly mediated by hypoxia inducible factor-1 (HIF-1) …
progression. The hypoxic response is mainly mediated by hypoxia inducible factor-1 (HIF-1) …
Sex and gender differences in kidney cancer: clinical and experimental evidence
AJ Peired, R Campi, ML Angelotti, G Antonelli, C Conte… - Cancers, 2021 - mdpi.com
Simple Summary Kidney cancer is a frequent malignant tumor that accounts for
approximately 5% of all cancer incidences. It affects both males and females, but males are …
approximately 5% of all cancer incidences. It affects both males and females, but males are …