Melatonin is uncommonly effective in reducing oxidative stress under a remarkably large
number of circumstances. It achieves this action via a variety of means: direct detoxification …

Endoplasmic reticulum (ER) is a dynamic organelle that participates in a number of cellular
functions by controlling lipid metabolism, calcium stores, and proteostasis. Under stressful …

Osteoarthritis (OA) is a degenerative joint disease characterized by progressive erosion of
articular cartilage. As chondrocytes are the only cell type forming the articular cartilage, their …

Melatonin has demonstrated a potential protective effect in central nervous system. Thus, it
is interesting to determine whether pre‐ischemia melatonin administration could protect …

Abstract Silent information regulator 1 (SIRT 1), a type of histone deacetylase, is a highly
effective therapeutic target for protection against ischemia reperfusion (IR) injury (IRI) …

Epigenetic modifications, including methylation or acetylation as well as post‐transcriptional
modifications, are mechanisms used by eukaryotic cells to increase the genome diversity in …

Melatonin functions as a crucial mediator of sterile neuroinflammation; however, the
underlying mechanisms remain poorly understood. Dysfunctional mitochondria, a main …

Ischemia/reperfusion (IR) injury occurs in many organs and tissues, and contributes to
morbidity and mortality worldwide. Melatonin, an endogenously produced indolamine …

Transplantation of adipose-derived mesenchymal stem cells (ADMSCs) can aid in the
treatment of numerous diseases in animals. However, natural aging during in vitro …

Maternal infection/inflammation represents one of the most important factors involved in the
etiology of brain injury in newborns. We investigated the modulating effect of prenatal …