Genetics of substance use disorders in the era of big data
J Gelernter, R Polimanti - Nature Reviews Genetics, 2021 - nature.com
Substance use disorders (SUDs) are conditions in which the use of legal or illegal
substances, such as nicotine, alcohol or opioids, results in clinical and functional …
substances, such as nicotine, alcohol or opioids, results in clinical and functional …
Molecular genetics of cocaine use disorders in humans
N Fernandez-Castillo, J Cabana-Dominguez… - Molecular …, 2022 - nature.com
Drug addiction, one of the major health problems worldwide, is characterized by the loss of
control in drug intake, craving, and withdrawal. At the individual level, drugs of abuse …
control in drug intake, craving, and withdrawal. At the individual level, drugs of abuse …
Using Mendelian randomization analysis to better understand the relationship between mental health and substance use: a systematic review
JL Treur, MR Munafò, E Logtenberg… - Psychological …, 2021 - cambridge.org
BackgroundPoor mental health has consistently been associated with substance use
(smoking, alcohol drinking, cannabis use, and consumption of caffeinated drinks). To …
(smoking, alcohol drinking, cannabis use, and consumption of caffeinated drinks). To …
[HTML][HTML] Adolescent ADHD and electrophysiological reward responsiveness: A machine learning approach to evaluate classification accuracy and prognosis
We evaluated event-related potential (ERP) indices of reinforcement sensitivity as ADHD
biomarkers by examining, in N= 306 adolescents (M age= 15.78, SD= 1.08), the extent to …
biomarkers by examining, in N= 306 adolescents (M age= 15.78, SD= 1.08), the extent to …
An overview on neurobiology and therapeutics of attention-deficit/hyperactivity disorder
BS Da Silva, EH Grevet, LCF Silva, JKN Ramos… - Discover Mental …, 2023 - Springer
Abstract Attention-Deficit/Hyperactivity Disorder (ADHD) is a prevalent psychiatric condition
characterized by developmentally inappropriate symptoms of inattention and/or …
characterized by developmentally inappropriate symptoms of inattention and/or …
Genetic architecture of ADHD and overlap with other psychiatric disorders and cognition-related phenotypes
Attention-deficit/hyperactivity disorder (ADHD) co-occurs with many other psychiatric
disorders and traits. In this review, we summarize and interpret the existing literature on the …
disorders and traits. In this review, we summarize and interpret the existing literature on the …
Genetic liability to ADHD and substance use disorders in individuals with ADHD
Aims 1) To investigate whether genetic liability to attention‐deficit/hyperactivity disorder
(ADHD), indexed by polygenic risk scores for ADHD (PRS‐ADHD), is associated with …
(ADHD), indexed by polygenic risk scores for ADHD (PRS‐ADHD), is associated with …
Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry
S Sanchez-Roige, P Fontanillas, MV Jennings… - Molecular …, 2021 - nature.com
The growing prevalence of opioid use disorder (OUD) constitutes an urgent health crisis.
Ample evidence indicates that risk for OUD is heritable. As a surrogate (or proxy) for OUD …
Ample evidence indicates that risk for OUD is heritable. As a surrogate (or proxy) for OUD …
Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization
Attention‐deficit hyperactivity disorder (ADHD) has consistently been associated with
substance use, but the nature of this association is not fully understood. To inform …
substance use, but the nature of this association is not fully understood. To inform …
Mendelian randomization analysis for attention deficit/hyperactivity disorder: studying a broad range of exposures and outcomes
M Soler Artigas, C Sánchez-Mora… - International journal …, 2023 - academic.oup.com
Background Attention deficit/hyperactivity disorder (ADHD) is a highly prevalent
neurodevelopmental disorder caused by a combination of genetic and environmental factors …
neurodevelopmental disorder caused by a combination of genetic and environmental factors …