Micronuclei are small membrane-bounded compartments with a DNA content encapsulated
by a nuclear envelope and spatially separated from the primary nucleus. Micronuclei have …

The terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay
detects DNA breakage by labeling the free 3ʹ-hydroxyl termini. Given that genomic DNA …

Genome editing has therapeutic potential for treating genetic diseases and cancer.
However, the currently most practicable approaches rely on the generation of DNA double …

Karyotype alterations have emerged as on-target complications from CRISPR-Cas9 genome
editing. However, the events that lead to these karyotypic changes in embryos after Cas9 …

Aneuploidy has been recognized as a hallmark of tumorigenesis for more than 100 years,
but the connection between chromosomal errors and malignant growth has remained …

Mitotic cell division is tightly monitored by checkpoints that safeguard the genome from
instability. Failures in accurate chromosome segregation during mitosis can cause …

Micronuclei are small DNA-containing nuclear structures that are spatially isolated from the
main nucleus. They are frequently found in pathologies, including cancer. It was recently …

Chromosomal instability (CIN) and epigenetic alterations are characteristics of advanced
and metastatic cancers,,–, but whether they are mechanistically linked is unknown. Here we …

Mutation of the human genome results in three classes of genomic variation: single
nucleotide variants; short insertions or deletions; and large structural variants (SVs). Some …

The nuclear envelope is often depicted as a static barrier that regulates access between the
nucleus and the cytosol. However, recent research has identified many conditions in …