Emerging epigenetic dynamics in gut-microglia brain axis: experimental and clinical implications for accelerated brain aging in schizophrenia

B Ben-Azu, EC Del Re, J VanderZwaag… - Frontiers in Cellular …, 2023 - frontiersin.org
Brain aging, which involves a progressive loss of neuronal functions, has been reported to
be premature in probands affected by schizophrenia (SCZ). Evidence shows that SCZ and …

Ketamine as a pharmacological tool for the preclinical study of memory deficit in schizophrenia

JES Santiago, GR Roldán, O Picazo - Behavioural Pharmacology, 2023 - journals.lww.com
Schizophrenia is a serious neuropsychiatric disorder characterized by the presence of
positive symptoms (hallucinations, delusions, and disorganization of thought and language) …

Geraniol attenuates behavioral and neurochemical impairments by inhibitions of HPA-axis and oxido-inflammatory perturbations in mice exposed to post-traumatic …

B Ben-Azu, OG Adebayo, EG Moke… - Journal of Psychiatric …, 2023 - Elsevier
Geraniol is an acyclic isoprenoid monoterpenoid analogue that has been shown to elicit
neuroprotective functions, primarily through its ability to stimulate antioxidant and anti …

Diosgenin alleviates alcohol-mediated escalation of social defeat stress and the neurobiological sequalae

B Ben-Azu, EG Moke, LE Chris-Ozoko… - …, 2024 - Springer
Rationale Emerging evidence indicates that persistent alcohol consumption escalates
psychosocial trauma achieved by social defeat stress (SDS)-induced neurobiological …

Normalization of HPA axis, cholinergic neurotransmission, and inhibiting brain oxidative and inflammatory dynamics are associated with the adaptogenic-like effect of …

JOT Emudainohwo, B Ben-Azu, OG Adebayo… - Journal of Molecular …, 2023 - Springer
Social defeat stress (SDS) due to changes in biochemical functions has been implicated in
the pathogenesis of affective and cognitive disorders. Employing pharmacological approach …

Reversal and preventive pleiotropic mechanisms involved in the antipsychotic-like effect of taurine, an essential β-amino acid in ketamine-induced experimental …

B Ben-Azu, CI Uruaka, AM Ajayi, TA Jarikre… - Neurochemical …, 2023 - Springer
Schizophrenia is a life disabling, multisystem neuropsychiatric disease mostly derived from
complex epigenetic-mediated neurobiological changes causing behavioural deficits …

[HTML][HTML] Kolaviron abates busulfan-induced episodic memory deficit and testicular dysfunction in rats: the implications for neuroendopathobiological changes during …

MO Oyovwi, B Ben-Azu, TP Edesiri, E Victor… - Biomedicine & …, 2021 - Elsevier
Busulfan is a popular antileukemia chemotherapeutic alkylating agent widely known to
induce variety of serious adverse effects including chemobrain-related cognitive …

Lipopolysaccharide exacerbates ketamine-induced psychotic-like behavior, oxidative stress, and neuroinflammation in mice: ameliorative effect of diosmin

AEO Eneni, B Ben-Azu, AM Ajayi… - Journal of Molecular …, 2023 - Springer
Schizophrenia, a neuropsychiatric disorder has been associated with aberrant
neurotransmission affecting behaviors, social preference, and cognition. Limitations in …

Epigallocatechin-gallate attenuates rapamycin exacerbated high fat diet-induced autophagy, hormonal dysregulation, testicular and brain oxidative stress, and …

CC Onyekweli, B Ben-Azu, OM Oyovwi… - Food and Chemical …, 2024 - Elsevier
This study investigated whether epigallocatechin-gallate (EGCG) could counteract the
detrimental effects of high-fat diet (HFD)-induced obesity in rats exposed to rapamycin …

Mechanisms underpinning Carpolobia lutea G. Don ethanol extract's neurorestorative and antipsychotic-like activities in an NMDA receptor antagonist model of …

NA Omeiza, A Bakre, B Ben-Azu, AA Sowunmi… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Persistent ketamine insults to the central nervous system
block NMDA receptors and disrupt putative neurotransmission, oxido–nitrosative, and …