Insights from genomic profiling of transcription factors
PJ Farnham - Nature Reviews Genetics, 2009 - nature.com
A crucial question in the field of gene regulation is whether the location at which a
transcription factor binds influences its effectiveness or the mechanism by which it regulates …
transcription factor binds influences its effectiveness or the mechanism by which it regulates …
ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia
SG Landt, GK Marinov, A Kundaje… - Genome …, 2012 - genome.cshlp.org
Chromatin immunoprecipitation (ChIP) followed by high-throughput DNA sequencing (ChIP-
seq) has become a valuable and widely used approach for mapping the genomic location of …
seq) has become a valuable and widely used approach for mapping the genomic location of …
Core transcriptional regulatory circuitry in human embryonic stem cells
The transcription factors OCT4, SOX2, and NANOG have essential roles in early
development and are required for the propagation of undifferentiated embryonic stem (ES) …
development and are required for the propagation of undifferentiated embryonic stem (ES) …
A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters
S Saxonov, P Berg, DL Brutlag - Proceedings of the …, 2006 - National Acad Sciences
A striking feature of the human genome is the dearth of CpG dinucleotides (CpGs)
interrupted occasionally by CpG islands (CGIs), regions with relatively high content of the …
interrupted occasionally by CpG islands (CGIs), regions with relatively high content of the …
[HTML][HTML] EZH2 is downstream of the pRB‐E2F pathway, essential for proliferation and amplified in cancer
AP Bracken, D Pasini, M Capra, E Prosperini… - The EMBO …, 2003 - embopress.org
Recent experiments have demonstrated that the Polycomb group (PcG) gene EZH2 is highly
expressed in metastatic prostate cancer and in lymphomas. EZH2 is a component of the …
expressed in metastatic prostate cancer and in lymphomas. EZH2 is a component of the …
Control of pancreas and liver gene expression by HNF transcription factors
The transcriptional regulatory networks that specify and maintain human tissue diversity are
largely uncharted. To gain insight into this circuitry, we used chromatin immunoprecipitation …
largely uncharted. To gain insight into this circuitry, we used chromatin immunoprecipitation …
Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1
Estrogen plays an essential physiologic role in reproduction and a pathologic one in breast
cancer. The completion of the human genome has allowed the identification of the …
cancer. The completion of the human genome has allowed the identification of the …
Analysis of transcription factor HY5 genomic binding sites revealed its hierarchical role in light regulation of development
J Lee, K He, V Stolc, H Lee, P Figueroa, Y Gao… - The Plant …, 2007 - academic.oup.com
The transcription factor LONG HYPOCOTYL5 (HY5) acts downstream of multiple families of
the photoreceptors and promotes photomorphogenesis. Although it is well accepted that …
the photoreceptors and promotes photomorphogenesis. Although it is well accepted that …
Genomic targets of the human c-Myc protein
PC Fernandez, SR Frank, L Wang… - Genes & …, 2003 - genesdev.cshlp.org
The transcription factor Myc is induced by mitogenic signals and regulates downstream
cellular responses. If overexpressed, Myc promotes malignant transformation. Myc …
cellular responses. If overexpressed, Myc promotes malignant transformation. Myc …