Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials

CM Zipser, JJ Cragg, JD Guest, MG Fehlings… - The Lancet …, 2022 - thelancet.com
Spinal cord injury is a severely disabling neurological condition leading to impaired mobility,
pain, and autonomic dysfunction. Most often, a single traumatic event, such as a traffic or …

Progression in translational research on spinal cord injury based on microenvironment imbalance

B Fan, Z Wei, S Feng - Bone research, 2022 - nature.com
Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level
and imposes a considerable burden on patients, families, and society. Repair of the injured …

Traumatic spinal cord injury

CS Ahuja, JR Wilson, S Nori, M Kotter… - Nature reviews Disease …, 2017 - nature.com
Traumatic spinal cord injury (SCI) has devastating consequences for the physical, social and
vocational well-being of patients. The demographic of SCIs is shifting such that an …

A first-in-human, phase I study of neural stem cell transplantation for chronic spinal cord injury

E Curtis, JR Martin, B Gabel, N Sidhu, TK Rzesiewicz… - Cell stem cell, 2018 - cell.com
We tested the feasibility and safety of human-spinal-cord-derived neural stem cell (NSI-566)
transplantation for the treatment of chronic spinal cord injury (SCI). In this clinical trial, four …

Immune response following traumatic spinal cord injury: Pathophysiology and therapies

RC Sterner, RM Sterner - Frontiers in immunology, 2023 - frontiersin.org
Traumatic spinal cord injury (SCI) is a devastating condition that is often associated with
significant loss of function and/or permanent disability. The pathophysiology of SCI is …

Clinical trials of stem cell therapy for cerebral ischemic stroke

M Kawabori, H Shichinohe, S Kuroda… - International Journal of …, 2020 - mdpi.com
Despite recent developments in innovative treatment strategies, stroke remains one of the
leading causes of death and disability worldwide. Stem cell therapy is currently attracting …

Introduction to stem cells and regenerative medicine

G Kolios, Y Moodley - Respiration, 2012 - karger.com
Stem cells are a population of undifferentiated cells characterized by the ability to
extensively proliferate (self-renewal), usually arise from a single cell (clonal), and …

The leading edge: Emerging neuroprotective and neuroregenerative cell-based therapies for spinal cord injury

CS Ahuja, A Mothe, M Khazaei… - Stem cells …, 2020 - academic.oup.com
Spinal cord injuries (SCIs) are associated with tremendous physical, social, and financial
costs for millions of individuals and families worldwide. Rapid delivery of specialized …

Restoration of sensorimotor functions after spinal cord injury

V Dietz, K Fouad - Brain, 2014 - academic.oup.com
The purpose of this review is to discuss the achievements and perspectives regarding
rehabilitation of sensorimotor functions after spinal cord injury. In the first part we discuss …

Functional regeneration of supraspinal connections in a patient with transected spinal cord following transplantation of bulbar olfactory ensheathing cells with …

P Tabakow, G Raisman, W Fortuna… - Cell …, 2014 - journals.sagepub.com
Treatment of patients sustaining a complete spinal cord injury remains an unsolved clinical
problem because of the lack of spontaneous regeneration of injured central axons. A 38 …