Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials
Spinal cord injury is a severely disabling neurological condition leading to impaired mobility,
pain, and autonomic dysfunction. Most often, a single traumatic event, such as a traffic or …
pain, and autonomic dysfunction. Most often, a single traumatic event, such as a traffic or …
Progression in translational research on spinal cord injury based on microenvironment imbalance
B Fan, Z Wei, S Feng - Bone research, 2022 - nature.com
Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level
and imposes a considerable burden on patients, families, and society. Repair of the injured …
and imposes a considerable burden on patients, families, and society. Repair of the injured …
Traumatic spinal cord injury
Traumatic spinal cord injury (SCI) has devastating consequences for the physical, social and
vocational well-being of patients. The demographic of SCIs is shifting such that an …
vocational well-being of patients. The demographic of SCIs is shifting such that an …
A first-in-human, phase I study of neural stem cell transplantation for chronic spinal cord injury
E Curtis, JR Martin, B Gabel, N Sidhu, TK Rzesiewicz… - Cell stem cell, 2018 - cell.com
We tested the feasibility and safety of human-spinal-cord-derived neural stem cell (NSI-566)
transplantation for the treatment of chronic spinal cord injury (SCI). In this clinical trial, four …
transplantation for the treatment of chronic spinal cord injury (SCI). In this clinical trial, four …
Immune response following traumatic spinal cord injury: Pathophysiology and therapies
RC Sterner, RM Sterner - Frontiers in immunology, 2023 - frontiersin.org
Traumatic spinal cord injury (SCI) is a devastating condition that is often associated with
significant loss of function and/or permanent disability. The pathophysiology of SCI is …
significant loss of function and/or permanent disability. The pathophysiology of SCI is …
Clinical trials of stem cell therapy for cerebral ischemic stroke
M Kawabori, H Shichinohe, S Kuroda… - International Journal of …, 2020 - mdpi.com
Despite recent developments in innovative treatment strategies, stroke remains one of the
leading causes of death and disability worldwide. Stem cell therapy is currently attracting …
leading causes of death and disability worldwide. Stem cell therapy is currently attracting …
Introduction to stem cells and regenerative medicine
Stem cells are a population of undifferentiated cells characterized by the ability to
extensively proliferate (self-renewal), usually arise from a single cell (clonal), and …
extensively proliferate (self-renewal), usually arise from a single cell (clonal), and …
The leading edge: Emerging neuroprotective and neuroregenerative cell-based therapies for spinal cord injury
CS Ahuja, A Mothe, M Khazaei… - Stem cells …, 2020 - academic.oup.com
Spinal cord injuries (SCIs) are associated with tremendous physical, social, and financial
costs for millions of individuals and families worldwide. Rapid delivery of specialized …
costs for millions of individuals and families worldwide. Rapid delivery of specialized …
Restoration of sensorimotor functions after spinal cord injury
The purpose of this review is to discuss the achievements and perspectives regarding
rehabilitation of sensorimotor functions after spinal cord injury. In the first part we discuss …
rehabilitation of sensorimotor functions after spinal cord injury. In the first part we discuss …
Functional regeneration of supraspinal connections in a patient with transected spinal cord following transplantation of bulbar olfactory ensheathing cells with …
P Tabakow, G Raisman, W Fortuna… - Cell …, 2014 - journals.sagepub.com
Treatment of patients sustaining a complete spinal cord injury remains an unsolved clinical
problem because of the lack of spontaneous regeneration of injured central axons. A 38 …
problem because of the lack of spontaneous regeneration of injured central axons. A 38 …