Hemiindigoids comprise a range of natural and synthetic scaffolds that share the same
aromatic hydrocarbon backbone as well as promising biological and optical properties. The …

Deemed as poorly represented in nature, aurones have been often overlooked by
researchers compared to other members of the flavonoid superfamily. However, over the …

Aurones are naturally occurring structural isomerides of flavones that have diverse
bioactivities including antiviral, antibacterial, antifungal, anti-inflammatory, antitumor …

Tuberculosis (TB) is a slow growing, potentially debilitating disease that has plagued
humanity for centuries and has claimed numerous lives across the globe. Concerted efforts …

Natural compounds are rich in pharmacological properties that are a hot topic in
pharmaceutical research. The quinoline ring plays important roles in many biological …

In this work, we report the synthesis of new pyrazole derivatives bearing amide and
sulfonamide frameworks from aza-aurones. Firstly, the intermediate spiropyrazolines were …

We designed and synthesized analogues of a previously identified biofilm inhibitor IIIC5 to
improve solubility, retain inhibitory activities, and to facilitate encapsulation into pH …

Diversity-Oriented Synthesis (DOS) represents a strategy to obtain molecule libraries with
diverse structural features starting from one common compound in limited steps of synthesis …

The resistance of tumors against anticancer drugs is a major impediment for chemotherapy.
Tumors often develop multidrug resistance as a result of the cellular efflux of …

Aurones, particular polyphenolic compounds belonging to the class of minor flavonoids and
overlooked for a long time, have gained significative attention in medicinal chemistry in …