The JAK/STAT pathway is a conserved metazoan signaling system that transduces cues
from extracellular cytokines into transcriptional changes in the nucleus. JAK/STAT signaling …

Highlights•Generation of neuronal diversity is tightly linked to epigenetic modifications.•
Targeted DamID (TaDa) allows cell type-specific analysis of chromatin modifications.•There …

Tumors evolve through the acquisition of increasingly aggressive traits associated with
dysplasia. This progression is accompanied by alterations in tumor mechanical properties …

Cancer tissue often comprises multiple tumor clones with distinct oncogenic alterations such
as Ras or Src activation, yet the mechanism by which tumor heterogeneity drives cancer …

Reproduction is paramount to animals. For it to be successful, a coordination of social
behavior, physiology, and gamete production is necessary. How are social cues perceived …

Drosophila ovarian Follicle Stem Cells (FSCs) present a favorable paradigm for
understanding how stem cell division and differentiation are balanced in communities where …

Whereas stem and progenitor cells proliferate to maintain tissue homeostasis, fully
differentiated cells exit the cell cycle. How cell identity and cell-cycle state are coordinated …

To progress towards differentiation, progeny of stem cells need to extinguish expression of
stem-cell maintenance genes. Failures in such mechanisms can drive tumorigenesis. In …

Neural circuit formation and function require that diverse neurons are specified in
appropriate numbers. Known strategies for controlling neuronal numbers involve regulating …

In the Drosophila testis, a group of stromal cells termed hub provides multiple niche signals
for the surrounding germline and somatic stem cells. Stem cells of both populations compete …