Atopic dermatitis: an expanding therapeutic pipeline for a complex disease

T Bieber - Nature reviews Drug discovery, 2022 - nature.com
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …

[HTML][HTML] Biomarkers in atopic dermatitis—a review on behalf of the International Eczema Council

Y Renert-Yuval, JP Thyssen, R Bissonnette… - Journal of Allergy and …, 2021 - Elsevier
Atopic dermatitis (AD) is a common yet complex skin disease, posing a therapeutic
challenge with increasingly recognized different phenotypes among variable patient …

[HTML][HTML] Type 2 inflammation contributes to skin barrier dysfunction in atopic dermatitis

LA Beck, MJ Cork, M Amagai, A De Benedetto… - JID Innovations, 2022 - Elsevier
Skin barrier dysfunction, a defining feature of atopic dermatitis (AD), arises from multiple
interacting systems. In AD, skin inflammation is caused by host–environment interactions …

[HTML][HTML] Pathophysiology of atopic dermatitis: Clinical implications

J Kim, BE Kim, DYM Leung - Allergy and asthma proceedings, 2019 - ncbi.nlm.nih.gov
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. Genetic
predisposition, epidermal barrier disruption, and dysregulation of the immune system are …

Interleukin‐13: targeting an underestimated cytokine in atopic dermatitis

T Bieber - Allergy, 2020 - Wiley Online Library
Atopic dermatitis (AD) is a common inflammatory skin condition that has traditionally been
considered a paradigmatic type 2 immunity (T2)‐driven disease. Interleukin (IL)‐4 and IL‐13 …

Type 2 chronic inflammatory diseases: targets, therapies and unmet needs

P Kolkhir, CA Akdis, M Akdis, C Bachert… - Nature Reviews Drug …, 2023 - nature.com
Over the past two decades, significant progress in understanding of the pathogenesis of type
2 chronic inflammatory diseases has enabled the identification of compounds for more than …

Tape strips detect distinct immune and barrier profiles in atopic dermatitis and psoriasis

H He, R Bissonnette, J Wu, A Diaz, ESC Proulx… - Journal of Allergy and …, 2021 - Elsevier
Background Our current understanding of atopic dermatitis (AD) and psoriasis
pathophysiology is largely derived from skin biopsy studies that cause scarring and may be …

[HTML][HTML] Neuroimmune communication regulating pruritus in atopic dermatitis

M Steinhoff, F Ahmad, A Pandey, A Datsi… - Journal of Allergy and …, 2022 - Elsevier
Atopic dermatitis (AD) is a common, chronic-relapsing inflammatory skin disease with
significant disease burden. Genetic and environmental trigger factors contribute to AD …

The IL-4, IL-13 and IL-31 pathways in atopic dermatitis

C Dubin, E Del Duca… - Expert review of clinical …, 2021 - Taylor & Francis
Introduction: Atopic dermatitis (AD) is the most common inflammatory skin disease. It has a
complex pathophysiology, with a combination of immune dysregulation and intrinsic barrier …

[HTML][HTML] The infectious complications of atopic dermatitis

V Wang, J Boguniewicz, M Boguniewicz… - Annals of Allergy, Asthma …, 2021 - Elsevier
Objective Atopic dermatitis (AD) is a chronic inflammatory skin disease that is complicated
by an increased risk for skin and systemic infections. Preventive therapy for AD is based on …