Small-molecule inhibitors of indoleamine 2, 3-dioxygenase-1 (IDO1) are emerging at the
vanguard of experimental agents in oncology. Here, pioneers of this new drug class provide …

The indole scaffold is found in a wide range of bioactive heterocycles and natural products.
Moreover, the indole moiety is considered as the active principle in several alkaloids such …

Based on its effects on both tumour cell intrinsic malignant properties as well as anti-tumour
immune responses, tryptophan catabolism has emerged as an important metabolic regulator …

Continuous-flow liquid phase oxidation chemistry in microreactors receives a lot of attention
as the reactor provides enhanced heat and mass transfer characteristics, safe use of …

Activation of the aryl hydrocarbon receptor (AHR) by environmental xenobiotic toxic
chemicals, for instance 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (dioxin), has been implicated in …

Tryptophan catabolism in cancer is increasingly being recognized as an important
microenvironmental factor that suppresses antitumor immune responses. It has been …

The tryptophan catabolic enzyme indoleamine 2, 3-dioxygenase-1 (IDO1) has attracted
enormous attention in driving cancer immunosuppression, neovascularization, and …

Tumor cells escape the immune surveillance system of the host through a process called
immune tolerance. Immunotherapy targets molecules that serve as checks and balances in …

Selectivity control in hydroarylation‐based C− H alkylation has been dominated by steric
interactions. A conceptually distinct strategy that exploits the programmed switch in the C− H …

Tryptophan catabolism mediated by indoleamine 2, 3-dioxygenase (IDO1) is an important
mechanism of peripheral immune tolerance contributing to tumoral immune resistance, and …