A decrease in the activity of the insulin signaling system of the brain, due to both central
insulin resistance and insulin deficiency, leads to neurodegeneration and impaired …

Awake craniotomy for brain tumor resection is becoming a standard of care for lesions
residing within or in close proximity to regions presumed to have language or sensorimotor …

Sevoflurane is commonly used in clinical anesthesia. However, some reports indicated that
Sevoflurane could induce mitochondrial injury and neuroapoptosis. Although the …

Reversible blood-brain barrier (BBB) disruption has been uniformly reported in several
animal models of postoperative cognitive dysfunction (POCD). Nevertheless, the precise …

As life expectancy increases and the population grows, the number of surgeries performed
each year is likely to continue to increase. We evaluated whether surgery with general …

Sevoflurane anesthesia induces cognitive impairment, which may lead to perioperative
neurocognitive disorders (PND). However, the factors and molecular mechanism underlying …

Sevoflurane, a commonly used inhaled anesthetic, can induce neuronal apoptosis in the
developing rodent brain and correlate with functional neurological impairment later in life …

The incidence of postoperative cognitive dysfunction (POCD) in orthopedic patients varies
from 16% to 45%, although it can be as high as 72%. As a consequence, the hospitalization …

Abstract Background Calcineurin (CaN) having a high expression in hippocampal neurons
is closely related to apoptosis. Pretreatment with nimodipine can lower the apoptosis rate of …

Postoperative cognitive dysfunction (POCD) remains one of the most common complications
following anesthesia and surgery (AS) in the elderly population. Calcium-mediated …