Colorectal carcinoma: a general overview and future perspectives in colorectal cancer
I Mármol, C Sánchez-de-Diego… - International journal of …, 2017 - mdpi.com
Colorectal cancer (CRC) is the third most common cancer and the fourth most common
cause of cancer-related death. Most cases of CRC are detected in Western countries, with its …
cause of cancer-related death. Most cases of CRC are detected in Western countries, with its …
Gold-based medicine: a paradigm shift in anti-cancer therapy?
CI Yeo, KK Ooi, ERT Tiekink - Molecules, 2018 - mdpi.com
A new era of metal-based drugs started in the 1960s, heralded by the discovery of potent
platinum-based complexes, commencing with cisplatin [(H3N) 2PtCl2], which are effective …
platinum-based complexes, commencing with cisplatin [(H3N) 2PtCl2], which are effective …
Medicinal applications of gold (I/III)-based complexes bearing N-heterocyclic carbene and phosphine ligands
B Dominelli, JDG Correia, FE Kuehn - Journal of Organometallic Chemistry, 2018 - Elsevier
Phosphines are the most studied ligands on gold-based metallodrugs, whereas N-
heterocyclic carbenes (NHCs) have been emerging in the past years as potential alternative …
heterocyclic carbenes (NHCs) have been emerging in the past years as potential alternative …
Coordination chemistry of 1, 3, 5-triaza-7-phosphatricyclo [3.3. 1.1] decane (PTA) and derivatives. Part III. Variations on a theme: Novel architectures, materials and …
A Guerriero, M Peruzzini, L Gonsalvi - Coordination Chemistry Reviews, 2018 - Elsevier
This review paper covers the recent (2010–2017) synthetic modifications of the water
soluble cage-like aminophosphine ligand 1, 3, 5-triaza-7-phosphatricyclo [3.3. 1.1] decane …
soluble cage-like aminophosphine ligand 1, 3, 5-triaza-7-phosphatricyclo [3.3. 1.1] decane …
Characterization of hydrophilic gold (I) N-heterocyclic carbene (NHC) complexes as potent TrxR inhibitors using biochemical and mass spectrometric approaches
O Karaca, V Scalcon, SM Meier-Menches… - Inorganic …, 2017 - ACS Publications
We report here on the synthesis of a series of mono-and dinuclear gold (I) complexes
exhibiting sulfonated bis (NHC) ligands and novel hydroxylated mono (NHC) Au (I) …
exhibiting sulfonated bis (NHC) ligands and novel hydroxylated mono (NHC) Au (I) …
Gold as a possible alternative to platinum-based chemotherapy for colon cancer treatment
Due to the increasing incidence and high mortality associated with colorectal cancer (CRC),
novel therapeutic strategies are urgently needed. Classic chemotherapy against CRC is …
novel therapeutic strategies are urgently needed. Classic chemotherapy against CRC is …
Alkynyl Gold (I) complexes derived from 3-hydroxyflavones as multi-targeted drugs against colon cancer
The design of multi-targeted drugs has gained considerable interest in the last decade
thanks to their advantages in the treatment of different diseases, including cancer. The …
thanks to their advantages in the treatment of different diseases, including cancer. The …
Novel antitumor adamantane–azole gold (I) complexes as potential inhibitors of thioredoxin reductase
A Garcia, RC Machado, RM Grazul, MTP Lopes… - JBIC Journal of …, 2016 - Springer
Gold complexes that could act as antitumor agents have attracted great attention.
Heterocyclic compounds and their metal complexes display a broad spectrum of …
Heterocyclic compounds and their metal complexes display a broad spectrum of …
Synthesis and biological evaluation of thiolate gold (i) complexes as thioredoxin reductase (TrxR) and glutathione reductase (GR) inhibitors
M Fereidoonnezhad, HA Mirsadeghi… - New Journal of …, 2019 - pubs.rsc.org
New gold (I) thiolate complexes [(PPh2py) Au (SR)](PPh2py= 2-(diphenylphosphino)
pyridine and SR= the deprotonated form of pyridine-2-thiol (HSpy, 1a), pyrimidine-2 thiol …
pyridine and SR= the deprotonated form of pyridine-2-thiol (HSpy, 1a), pyrimidine-2 thiol …
Proteasome versus thioredoxin reductase competition as possible biological targets in antitumor mixed thiolate-dithiocarbamate gold (III) complexes
J Quero, S Cabello, T Fuertes, I Mármol… - Inorganic …, 2018 - ACS Publications
New mixed gold (III) derivatives with dithiocarbamate and thiolate ligands have been
synthesized and characterized. They display high anticancer activity against colon cancer …
synthesized and characterized. They display high anticancer activity against colon cancer …