Cellular biology of fracture healing

CS Bahney, RL Zondervan, P Allison… - Journal of …, 2019 - Wiley Online Library
The biology of bone healing is a rapidly developing science. Advances in transgenic and
gene‐targeted mice have enabled tissue and cell‐specific investigations of skeletal …

The roles of signaling pathways in bone repair and regeneration

M Majidinia, A Sadeghpour… - Journal of cellular …, 2018 - Wiley Online Library
Regenerative medicine has sparked interest in potential strategies for bone repair. Bone
defects are widespread and could be caused by trauma, congenital malformations …

Osteoblast/osteoclast and immune cocktail therapy of an exosome/drug delivery multifunctional hydrogel accelerates fracture repair

B Mi, L Chen, Y Xiong, Y Yang, AC Panayi, H Xue… - ACS …, 2022 - ACS Publications
The osteoblast/osteoclast and M1/M2 macrophage ratios play critical roles in delayed
fracture healing. Robust osteoblast differentiation and M2 macrophage polarization can …

Interleukin-6 signaling mediates cartilage degradation and pain in posttraumatic osteoarthritis in a sex-specific manner

Y Liao, Y Ren, X Luo, AJ Mirando, JT Long… - Science …, 2022 - science.org
Osteoarthritis (OA) and posttraumatic OA (PTOA) are caused by an imbalance in catabolic
and anabolic processes in articular cartilage and proinflammatory changes throughout the …

STING suppresses bone cancer pain via immune and neuronal modulation

K Wang, CR Donnelly, C Jiang, Y Liao, X Luo… - Nature …, 2021 - nature.com
Patients with advanced stage cancers frequently suffer from severe pain as a result of bone
metastasis and bone destruction, for which there is no efficacious treatment. Here, using …

Age-associated callus senescent cells produce TGF-β1 that inhibits fracture healing in aged mice

J Liu, J Zhang, X Lin, BF Boyce… - The Journal of clinical …, 2022 - Am Soc Clin Investig
Cellular senescence plays an important role in human diseases, including osteoporosis and
osteoarthritis. Senescent cells (SCs) produce the senescence-associated secretory …

Notch signaling and the skeleton

S Zanotti, E Canalis - Endocrine reviews, 2016 - academic.oup.com
Notch 1 to 4 receptors are important determinants of cell fate and function, and Notch
signaling plays an important role in skeletal development and bone remodeling. After direct …

Bone vasculature and bone marrow vascular niches in health and disease

J Chen, M Hendriks, A Chatzis… - Journal of Bone and …, 2020 - academic.oup.com
Bone vasculature and bone marrow vascular niches supply oxygen, nutrients, and secrete
angiocrine factors required for the survival, maintenance, and self‐renewal of stem and …

PD-1 blockade inhibits osteoclast formation and murine bone cancer pain

K Wang, Y Gu, Y Liao, S Bang… - The Journal of …, 2020 - Am Soc Clin Investig
Emerging immune therapy, such as with the anti–programmed cell death–1 (anti–PD-1)
monoclonal antibody nivolumab, has shown efficacy in tumor suppression. Patients with …

Degradation of the NOTCH intracellular domain by elevated autophagy in osteoblasts promotes osteoblast differentiation and alleviates osteoporosis

G Yoshida, T Kawabata, H Takamatsu, S Saita… - Autophagy, 2022 - Taylor & Francis
Maintenance of bone integrity is mediated by the balanced actions of osteoblasts and
osteoclasts. Because macroautophagy/autophagy regulates osteoblast mineralization …