The 4 mammalian arrestins serve as almost universal regulators of the largest known family
of signaling proteins, G-protein-coupled receptors (GPCRs). Arrestins terminate receptor …

Almost 25 years after the first report that glutamate can activate receptors coupled to
heterotrimeric G-proteins, tremendous progress has been made in the field of metabotropic …

Stimulation of Group I metabotropic glutamate receptors (mGluR1 and mGluR5) leads to
activation of a wide variety of signalling pathways. mGluRs couple to Gαq/11 proteins …

Metabotropic glutamate receptors (mGluRs) comprise a unique family of G protein-coupled
receptors (GPCR) that can be classified into 3 groups based on G protein coupling …

Plasticity of feedforward inhibition in the hippocampal mossy fiber (MF) pathway can
dramatically influence dentate gyrus-CA3 dialog. Interestingly, MF inputs to CA3 stratum …

Purpose: Metabotropic glutamate receptors (mGluR) play a variety of roles in both neuronal
and nonneuronal cells. Recently, we reported that mGluR4 mediates 5-fluorouracil …

Metabotropic glutamate receptors (mGluRs) play important roles in neurotransmission,
neuronal development, synaptic plasticity, and neurological disorders. Recent studies have …

G protein-coupled receptors (GPCRs) are involved in many biological processes. Therefore,
GPCR function is tightly controlled both at receptor level and at the level of signalling …

The metabotropic glutamate receptors (mGlu receptors) are G protein-coupled receptors that
bind to the excitatory neurotransmitter glutamate and are important in the modulation of …

The G-protein coupled receptor (GPCR) metabotropic glutamate receptor 7 (mGluR7) is
widely expressed throughout the nervous system and is implicated in diverse physiological …