The underlying physical properties of microfluidic tools have led to new biological insights
through the development of microsystems that can manipulate, mimic and measure biology …

Information about developmental gene expression resides in defined regulatory elements,
called enhancers, in the non-coding part of the genome. Although cells reliably utilize …

Divergent morphology of species has largely been ascribed to genetic differences in the
tissue-specific expression of proteins, which could be achieved by divergence in cis …

One of the most important questions in biology is how transcription factors (TFs) and
cofactors control enhancer function and thus gene expression. Enhancer activation usually …

Extensive transcriptional networks play major roles in cellular and organismal functions.
Transcript levels are in part determined by the combinatorial and overlapping functions of …

Wood remains the world's most abundant and renewable resource for timber and pulp and
is an alternative to fossil fuels. Understanding the molecular regulation of wood formation …

Background Site-specific transcription factors (TFs) bind DNA regulatory elements to control
expression of target genes, forming the core of gene regulatory networks. Despite decades …

During development, neural progenitors are temporally patterned to sequentially generate a
variety of neural types. In Drosophila neural progenitors called neuroblasts, temporal …

Combinatorial interactions among transcription factors (TFs) play essential roles in
generating gene expression specificity and diversity in metazoans. Using yeast 2-hybrid …

Many tools are available to analyse genomes but are often challenging to use in a cell type–
specific context. We have developed a method similar to the isolation of nuclei tagged in a …