Microfluidics: reframing biological enquiry
The underlying physical properties of microfluidic tools have led to new biological insights
through the development of microsystems that can manipulate, mimic and measure biology …
through the development of microsystems that can manipulate, mimic and measure biology …
Deciphering the transcriptional cis-regulatory code
Information about developmental gene expression resides in defined regulatory elements,
called enhancers, in the non-coding part of the genome. Although cells reliably utilize …
called enhancers, in the non-coding part of the genome. Although cells reliably utilize …
Conservation of transcription factor binding specificities across 600 million years of bilateria evolution
Divergent morphology of species has largely been ascribed to genetic differences in the
tissue-specific expression of proteins, which could be achieved by divergence in cis …
tissue-specific expression of proteins, which could be achieved by divergence in cis …
Transcriptional regulators form diverse groups with context-dependent regulatory functions
G Stampfel, T Kazmar, O Frank, S Wienerroither… - Nature, 2015 - nature.com
One of the most important questions in biology is how transcription factors (TFs) and
cofactors control enhancer function and thus gene expression. Enhancer activation usually …
cofactors control enhancer function and thus gene expression. Enhancer activation usually …
[HTML][HTML] A genome-scale resource for the functional characterization of Arabidopsis transcription factors
Extensive transcriptional networks play major roles in cellular and organismal functions.
Transcript levels are in part determined by the combinatorial and overlapping functions of …
Transcript levels are in part determined by the combinatorial and overlapping functions of …
Hierarchical Transcription Factor and Chromatin Binding Network for Wood Formation in Populus trichocarpa
Wood remains the world's most abundant and renewable resource for timber and pulp and
is an alternative to fossil fuels. Understanding the molecular regulation of wood formation …
is an alternative to fossil fuels. Understanding the molecular regulation of wood formation …
Spatial expression of transcription factors in Drosophilaembryonic organ development
AS Hammonds, CA Bristow, WW Fisher, R Weiszmann… - Genome biology, 2013 - Springer
Background Site-specific transcription factors (TFs) bind DNA regulatory elements to control
expression of target genes, forming the core of gene regulatory networks. Despite decades …
expression of target genes, forming the core of gene regulatory networks. Despite decades …
A comprehensive temporal patterning gene network in Drosophila medulla neuroblasts revealed by single-cell RNA sequencing
During development, neural progenitors are temporally patterned to sequentially generate a
variety of neural types. In Drosophila neural progenitors called neuroblasts, temporal …
variety of neural types. In Drosophila neural progenitors called neuroblasts, temporal …
A comprehensive Drosophila melanogaster transcription factor interactome
Combinatorial interactions among transcription factors (TFs) play essential roles in
generating gene expression specificity and diversity in metazoans. Using yeast 2-hybrid …
generating gene expression specificity and diversity in metazoans. Using yeast 2-hybrid …
Cell type–specific genomics of Drosophila neurons
Many tools are available to analyse genomes but are often challenging to use in a cell type–
specific context. We have developed a method similar to the isolation of nuclei tagged in a …
specific context. We have developed a method similar to the isolation of nuclei tagged in a …