Immunotherapy has recently garnered plenty of attention to improve the clinical outcomes in
the treatment of various diseases. However, owing to the dynamic nature of the immune …

Introduction A microneedle array patch (MAP) has been studied as a means for delivering
drugs or vaccines and has shown superior delivery efficiency compared to the conventional …

Microneedles (MNs) have gained increasing attention in the biomedical field, owing to their
notable advantages over injectable and transdermal preparations. The mechanical …

Highlights•Allergen immunotherapy is the only approach for inducing long-term immune
tolerance toward allergens.•Skin-based allergen therapy shows promise, given the …

Aim: Epicutaneous immunotherapy (EPIT) with peanut has been demonstrated to be safe
but efficacy may be limited by allergen uptake through the skin barrier. To enhance allergen …

The prevalence of peanut allergies has escalated over the last 20 years, yet there are no
FDA approved treatments for peanut allergies. In this study we evaluated the potential of …

Microneedles (MNs) have been extensively explored in the literature as a means to deliver
drugs in the skin, surpassing the stratum corneum permeability barrier. MNs are potentially …

As a prospective influenza vaccination platform, a microneedle patch offers advantages
such as self-administration and reduction of needle-phobia-associated vaccination …

Cells, exosomes, and nucleic acids play crucial roles in biomedical engineering, holding
substantial clinical potential. However, their utility is often hindered by various drawbacks …

Subcutaneous allergen immunotherapy has been practiced clinically for decades to treat
airborne allergies. Recently, the cutaneous route, which exploits the immunocompetence of …