Insula function is considered critical for many motivated behaviors, with proposed functions
ranging from attention, behavioral control, emotional regulation, goal-directed and aversion …

Methamphetamine is a widely abused psychostimulant. It reverses transport through the
dopamine transporter, thereby increasing the extracellular level of dopamine in the brain …

Substance use disorders (SUDs) are a growing public health concern with only a limited
number of approved treatments. However, even approved treatments are subject to limited …

Abstract MCGREGOR, MS, and RT LaLumiere. Still a “hidden island”? The rodent insular
cortex in drug seeking, reward, and risk. NEUROSCI BIOBEHAV REV 21 (1) XXX-XXX …

Alcohol use disorder is a substantial social and economic burden. During the last years, the
number of women with drinking problems has been increasing, and one main concern is …

Humans with alcohol use disorder typically abstain because of the negative consequences
associated with excessive drinking, and exposure to contexts previously associated with …

Binge or chronic alcohol consumption causes neuroinflammation and leads to alcohol use
disorder (AUD). AUD not only affects the central nervous system (CNS) but also leads to …

Inhibitory control hierarchically regulates cognitive and emotional systems in the service of
adaptive goal-directed behavior across changing task demands and environments. While …

One of the most pernicious characteristics of alcohol use disorder is the compulsion to drink
despite negative consequences. The insular cortex controls decision making under …

Understanding brain structures and circuits impacted by alcohol use disorder is critical for
improving our future prevention techniques and treatment options. A brain region that has …