Pathological evaluation is the gold standard for identifying processes related to multiple
sclerosis that explain disease manifestations, and for guiding the development of new …

MRI has become the most important paraclinical tool for diagnosing and monitoring patients
with multiple sclerosis (MS). However, conventional MRI sequences are largely nonspecific …

Disturbance of cerebral iron regulation is almost universal in neurodegenerative disorders.
There is a growing body of evidence that increased iron deposits may contribute to …

Iron is considered to play a key role in the development and progression of Multiple
Sclerosis (MS). In particular, iron that accumulates in myeloid cells after the blood-brain …

Objectives To evaluate changes in T1 and T2* relaxometry of dentate nuclei (DN) with
respect to the number of previous administrations of Gadolinium-based contrast agents …

Objectives Conventional MRI is not sensitive to many pathological processes underpinning
multiple sclerosis (MS) ongoing in normal appearing brain tissue (NABT). Quantitative MRI …

Objective: We aimed to examine the regulation of lipocalin-2 (LCN2) in multiple sclerosis
(MS) and its potential functional relevance with regard to myelination and …

Objective: We investigated longitudinal changes in iron concentration in the subcortical gray
matter (caudate nucleus, globus pallidus, putamen, thalamus) of patients with clinically …

Iron has long been implicated in many neurological and other organ diseases. It is known
that over and above the normal increases in iron with age, in certain diseases there is an …

Despite robust postmortem evidence and potential clinical importance of gray matter (GM)
pathology in multiple sclerosis (MS), assessing GM damage by conventional magnetic …