Immune checkpoint therapy—current perspectives and future directions
P Sharma, S Goswami, D Raychaudhuri, BA Siddiqui… - Cell, 2023 - cell.com
Immune checkpoint therapy (ICT) has dramatically altered clinical outcomes for cancer
patients and conferred durable clinical benefits, including cure in a subset of patients …
patients and conferred durable clinical benefits, including cure in a subset of patients …
Early detection of cancer
Survival improves when cancer is detected early. However,~ 50% of cancers are at an
advanced stage when diagnosed. Early detection of cancer or precancerous change allows …
advanced stage when diagnosed. Early detection of cancer or precancerous change allows …
[HTML][HTML] Tumor immune contexture is a determinant of anti-CD19 CAR T cell efficacy in large B cell lymphoma
Axicabtagene ciloleucel (axi-cel) is an anti-CD19 chimeric antigen receptor (CAR) T cell
therapy approved for relapsed/refractory large B cell lymphoma (LBCL) and has treatment …
therapy approved for relapsed/refractory large B cell lymphoma (LBCL) and has treatment …
[HTML][HTML] Spatial architecture of the immune microenvironment orchestrates tumor immunity and therapeutic response
T Fu, LJ Dai, SY Wu, Y Xiao, D Ma, YZ Jiang… - Journal of hematology & …, 2021 - Springer
Tumors are not only aggregates of malignant cells but also well-organized complex
ecosystems. The immunological components within tumors, termed the tumor immune …
ecosystems. The immunological components within tumors, termed the tumor immune …
Personalized circulating tumor DNA analysis as a predictive biomarker in solid tumor patients treated with pembrolizumab
Immune checkpoint blockade (ICB) provides clinical benefit to a subset of patients with
cancer. However, existing biomarkers do not reliably predict treatment response across …
cancer. However, existing biomarkers do not reliably predict treatment response across …
[HTML][HTML] Immunogenic cell death, DAMPs and prothymosin α as a putative anticancer immune response biomarker
AI Birmpilis, A Paschalis, A Mourkakis, P Christodoulou… - Cells, 2022 - mdpi.com
The new and increasingly studied concept of immunogenic cell death (ICD) revealed a
previously unknown perspective of the various regulated cell death (RCD) modalities …
previously unknown perspective of the various regulated cell death (RCD) modalities …
[HTML][HTML] A variational algorithm to detect the clonal copy number substructure of tumors from scRNA-seq data
Single-cell RNA sequencing is the reference technology to characterize the composition of
the tumor microenvironment and to study tumor heterogeneity at high resolution. Here we …
the tumor microenvironment and to study tumor heterogeneity at high resolution. Here we …
[HTML][HTML] Germline genetic contribution to the immune landscape of cancer
Understanding the contribution of the host's genetic background to cancer immunity may
lead to improved stratification for immunotherapy and to the identification of novel …
lead to improved stratification for immunotherapy and to the identification of novel …
[HTML][HTML] Hypoxia and the phenomenon of immune exclusion
V Pietrobon, FM Marincola - Journal of Translational Medicine, 2021 - Springer
Over the last few years, cancer immunotherapy experienced tremendous developments and
it is nowadays considered a promising strategy against many types of cancer. However, the …
it is nowadays considered a promising strategy against many types of cancer. However, the …
Pancancer transcriptomic profiling identifies key PANoptosis markers as therapeutic targets for oncology
Resistance to programmed cell death (PCD) is a hallmark of cancer. While some PCD
components are prognostic in cancer, the roles of many molecules can be masked by …
components are prognostic in cancer, the roles of many molecules can be masked by …