RNA adopts 3D structures that confer varied functional roles in human biology and
dysfunction in disease. Approaches to therapeutically target RNA structures with small …

Recent advances in our understanding of RNA biology have uncovered crucial roles for
RNA in multiple disease states, ranging from viral and bacterial infections to cancer and …

Target occupancy is often insufficient to elicit biological activity, particularly for RNA,
compounded by the longstanding challenges surrounding the molecular recognition of RNA …

RNA offers nearly unlimited potential as a target for small molecule chemical probes and
lead medicines. Many RNAs fold into structures that can be selectively targeted with small …

Although the potential value of RNA as a target for new small molecule therapeutics is
becoming increasingly credible, the physicochemical properties required for small …

The structural and regulatory elements in therapeutically relevant RNAs offer many
opportunities for targeting by small molecules, yet fundamental understanding of what drives …

Simple, rapid, and accurate detection methods for saccharides are potentially applicable to
various fields such as clinical and food chemistry. However, the practical applications of on …

Small molecule-based modulation of a triple helix in the long non-coding RNA metastasis-
associated lung adenocarcinoma transcript 1 (MALAT1) has been proposed as an attractive …

Overcoming the synthetic burden related to covalently connected receptors with appropriate
indicators for sensing various analytes via an indicator spacer receptor (ISR) approach, the …

Introduction The field of RNA-targeted small molecules is rapidly evolving, owing to the
advances in experimental and computational technologies. With the identification of several …