Nucleic acids are excellent at recognizing complementary sequences through the formation
of Watson− Crick base pairs. Since the base pairing enables the highly selective …

When Szent-Györgyi called water the “matrix of life”, 1 he was echoing an old sentiment.
Paracelsus in the 16th century said that “water was the matrix of the world and of all its …

Cancer and neurodegenerative diseases are caused by genetic and environmental factors.
Expression of tumour suppressor genes is suppressed by mutations or epigenetic silencing …

The effect of molecular crowding on the structure and stability of biomolecules has become a
subject of increasing interest because it can clarify how biomolecules behave under cell …

Among the multitude of chemical modifications that have been described over the past two
decades, oligonucleotide analogs that are modified at the 2′‐position of the furanose sugar …

Although fluorine is not a naturally occurring component of genetic material, fluorine-
containing drugs have many medical applications.[1] Fluorine is highly electronegative, and …

Nucleic acids (DNA and RNA) dynamically fold and unfold to exert their functions in cells.
These folding and unfolding behaviours are also the basis for various technical applications …

The thermodynamics of DNA duplex structures in the presence of high concentrations of
cosolutes in solution were investigated to discern nucleic acid structures and functions in …

Various chemical modifications are currently being evaluated for improving the efficacy of
short interfering RNA (siRNA) duplexes as antisense agents for gene silencing in vivo …

DNA forms not only the canonical duplex structure but also non-canonical structures. Most
potential sequences that induce the formation of non-canonical structures are present in …