Genetic engineering for heterologous expression has advanced in recent years. Model
systems such as Escherichia coli, Bacillus subtilis and Pichia pastoris are often used as host …

The combination of the insufficient availability and the complex structure of siamenoside I
(SI), the sweetest glucoside isolated from Siraitia grosvenorii to date, limited its use as a …

l-asparaginases catalyze the asparagine hydrolysis to aspartate. These enzymes play an
important role in the treatment of acute lymphoblastic leukemia because these cells are …

Abstract l-Asparaginase (l-ASNase) is a key enzyme used to treat acute lymphoblastic
leukemia, a childhood blood cancer. Here, we report on the characterization of a …

Bioactive compounds from endophytes have been used to treat various diseases. In the
present study, L-Asparaginase producing endophytes were isolated from Ocimum …

The potential use of asparaginases has gained tremendous significance in the treatment of
acute lymphoblastic leukemia (ALL). Earlier studies suggest L-asparaginases (L-ASP) …

Physical and chemical factors influencing the anti-leukemic l-asparaginase enzyme
production by Bacillus subtilis VUVD001 were optimized using multi-stage optimization on …

Abstract l-asparaginase is one of the most important and widely used drugs in the treatment
of leukemia. Like other proteinous drugs, this enzyme suffers from difficulties in the out-of …

This study was aimed to predict the 3D model of L-asparaginase from F. solani CLR-36
along with the prediction of the protein active site and evaluation of the L-asparagine-ligand …

The interaction between three methoxylated polybrominated diphenyl ethers (MeO-PBDEs)
and lysozyme was investigated using two complementary techniques: computational …