Branched-chain amino acids (BCAAs) are critical for skeletal muscle and whole-body
anabolism and energy homeostasis. They also serve as signaling molecules, for example …

Excessive sugar consumption and defective glucose sensing by hepatocytes contribute to
the development of metabolic diseases including type 2 diabetes mellitus (T2DM) and …

Branched-chain amino acids (BCAA) are strongly associated with dysregulated glucose and
lipid metabolism, but the underlying mechanisms are poorly understood. We report that …

Lipogenesis in liver is highest in the postprandial state; insulin activates SREBP-1c, which
transcriptionally activates genes involved in FA synthesis, whereas glucose activates …

With the identification of ChREBP in 2001, our interest in understanding the molecular
control of carbohydrate sensing has surged. While ChREBP was initially studied as a master …

Carbohydrate response element-binding protein (ChREBP) plays an important role in the
development of type 2 diabetes, dyslipidemia, and non-alcoholic fatty liver disease, as well …

Nonalcoholic fatty liver disease (NAFLD) is associated with all features of the metabolic
syndrome. Although deposition of excess triglycerides within liver cells, a hallmark of …

Carbohydrate metabolism is essential for cellular energy balance as well as for the
biosynthesis of new cellular building blocks. As animal nutrient intake displays temporal …

Brown adipose tissue (BAT) is a therapeutic target for metabolic diseases; thus,
understanding its metabolic circuitry is clinically important. Many studies of BAT compare …

Lipasin (also known as C19ORF80, RIFL, ANGPTL8 and betatrophin) is a newly discovered
circulating factor that regulates lipid metabolism and promotes pancreatic β-cell proliferation …