The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome
biogenesis is the process that generates ribosomes and plays an essential role in cell …

In this Review, we explore natural product antibiotics that do more than simply inhibit an
active site of an essential enzyme. We review these compounds to provide inspiration for the …

As the threat of antimicrobial-resistant bacteria compromises the safety and efficacy of
modern healthcare practices, the search for effective treatments is more urgent than ever …

Aminoglycosides (AGs) are long-known molecules successfully used against Gram-negative
pathogens. While their use declined with the discovery of new antibiotics, they are now …

Faithful translation of messenger RNA (mRNA) into protein is essential to maintain protein
homeostasis in the cell. Spontaneous translation errors are very rare due to stringent …

Microbial communities are continuously exposed to unpredictable changes in their
environment. To thrive in such dynamic habitats, microorganisms have developed the ability …

Mycobacterium abscessus (Mab), a nontuberculous mycobacterial (NTM) species, is an
emerging pathogen with high intrinsic drug resistance. Current standard-of-care therapy …

Background Aptamers are screened via the systematic evolution of ligands by exponential
enrichment (SELEX) and are widely used in molecular diagnostics and targeted therapies …

The streptothricin natural product mixture (also known as nourseothricin) was discovered in
the early 1940s, generating intense initial interest because of excellent gram-negative …

Ribosome-enhanced translational miscoding of the genetic code causes protein dysfunction
and loss of cellular fitness. During evolution, open reading frame length increased …