Early in its evolution, Enterococcus faecium acquired traits that allowed it to become a
successful nosocomial pathogen. E. faecium inherent tenacity to build resistance to …

Vancomycin-resistant enterococci (VRE) are important nosocomial pathogens. Invasive VRE
infections are difficult to treat since common therapeutic options including ampicillin and …

Objectives WGS-based antimicrobial susceptibility testing (AST) is as reliable as phenotypic
AST for several antimicrobial/bacterial species combinations. However, routine use of WGS …

Enterococcus faecalis, Enterococcus faecium and Staphylococcus aureus are both common
commensals and major opportunistic human pathogens. In recent decades, these bacteria …

Enterococcus faecium is a major species in infections by vancomycin-resistant enterococci
(VRE). New variants of the pathogen have emerged and become dominant in healthcare …

Background Heteroresistance refers to subpopulation-mediated differential antimicrobial
susceptibility within a clonal bacterial population. Usually, it designates a resistant …

The rapid and accurate detection of antimicrobial resistance is critical to limiting the spread
of infections and delivering effective treatments. Here, we developed a rapid, sensitive, and …

Acquisition and expression of antimicrobial resistance (AMR) mechanisms in bacteria are
often associated with a fitness cost. Thus, evolutionary adaptation and fitness cost …

Introduction: The rapid detection of resistance is a challenge for clinical microbiologists who
wish to prevent deleterious individual and collective consequences such as (i) delaying …

We report an outbreak of vancomycin-variable vanA+ enterococci (VVE) able to escape
phenotypic detection by current guidelines and demonstrate the molecular mechanisms for …