Extending the “one strain many compounds”(OSMAC) principle to marine microorganisms
Genomic data often highlights an inconsistency between the number of gene clusters
identified using bioinformatic approaches as potentially producing secondary metabolites …
identified using bioinformatic approaches as potentially producing secondary metabolites …
Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics
Covering: up to 2014 Dithiolopyrrolone (DTP) group antibiotics were first isolated in the early
half of the 20th century, but only recently has research been reawakened by insights gained …
half of the 20th century, but only recently has research been reawakened by insights gained …
[HTML][HTML] Isolation and characterization of actinobacteria from Algerian Sahara soils with antimicrobial activities
H Mohamed, B Miloud, F Zohra… - … journal of molecular …, 2017 - ncbi.nlm.nih.gov
Extreme ecosystems can be a source of untapped microorganisms to produce novel
bioactive compounds of industrial interest. Consequently, in this work, 32 actinomycetes …
bioactive compounds of industrial interest. Consequently, in this work, 32 actinomycetes …
The fish pathogen Yersinia ruckeri produces holomycin and uses an RNA methyltransferase for self-resistance
Holomycin and its derivatives belong to a class of broad-spectrum antibacterial natural
products containing a rare dithiolopyrrolone heterobicyclic scaffold. The antibacterial …
products containing a rare dithiolopyrrolone heterobicyclic scaffold. The antibacterial …
Precursor-directed biosynthesis of new dithiolopyrrolone analogs by Saccharothrix algeriensis NRRL B-24137
The natural dithiolopyrrolone antibiotics, produced during fermentation by Saccharothrix
algeriensis NRRL B-24137, are known for their potent antibacterial, antifungal, and …
algeriensis NRRL B-24137, are known for their potent antibacterial, antifungal, and …
New dithiolopyrrolone antibiotics induced by adding sorbic acid to the culture medium of Saccharothrix algeriensis NRRL B-24137
Dithiolopyrrolone antibiotics, produced by several microorganisms, are known for their
strong antimicrobial activities. This class of antibiotics generated new interest after the …
strong antimicrobial activities. This class of antibiotics generated new interest after the …
Identification and heterologous expression of the biosynthetic gene cluster for holomycin produced by Streptomyces clavuligerus
S Huang, Y Zhao, Z Qin, X Wang, M Onega, L Chen… - Process …, 2011 - Elsevier
Holomycin is a dithiolopyrrolone antibiotic natural product produced by Streptomyces
clavuligerus, ATCC 27064. This paper reports on the identification of a gene cluster from S …
clavuligerus, ATCC 27064. This paper reports on the identification of a gene cluster from S …
Newly Streptomyces-Induced Rabelomycin after Specific Amino Acid Supplementations: Experimental and Computational Investigations of Reactivities
S Tata, NEH Bensiradj, A Yekkour, S Snini… - Waste and Biomass …, 2024 - Springer
Streptomyces sp. PAL 114, is an actinobacterium isolated from Saharan soil. This strain was
previously shown to produce various angucyclines-type antibiotics. This class of molecule …
previously shown to produce various angucyclines-type antibiotics. This class of molecule …
Effects of sugar and amino acid supplementation on Aureobasidium pullulans NRRL 58536 antifungal activity against four Aspergillus species
S Prasongsuk, S Ployngam, S Wacharasindhu… - Applied microbiology …, 2013 - Springer
Cultured cell extracts from ten tropical strains of Aureobasidium pullulans were screened for
antifungal activity against four pathogenic Aspergillus species (Aspergillus flavus …
antifungal activity against four pathogenic Aspergillus species (Aspergillus flavus …
A new dithiolopyrrolone antibiotic triggered by a long fermentation of Saccharothrix algeriensis NRRL B‐24137 in sorbic acid‐amended medium
R Merrouche, A Yekkour, Y Coppel… - Letters in applied …, 2019 - academic.oup.com
Saccharothrix algeriensis NRRL B‐24137 is an actinobacterium isolated from Algerian
Saharan soil. It produces bioactive compounds belonging to the dithiolopyrrolone class of …
Saharan soil. It produces bioactive compounds belonging to the dithiolopyrrolone class of …