The concept of intrinsic versus extrinsic apoptosis

L Lossi - Biochemical Journal, 2022 - portlandpress.com
Regulated cell death is a vital and dynamic process in multicellular organisms that maintains
tissue homeostasis and eliminates potentially dangerous cells. Apoptosis, one of the better …

Neuronal cell death

M Fricker, AM Tolkovsky, V Borutaite… - Physiological …, 2018 - journals.physiology.org
Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

Comprehensive insights into the multi-antioxidative mechanisms of melanin nanoparticles and their application to protect brain from injury in ischemic stroke

Y Liu, K Ai, X Ji, D Askhatova, R Du… - Journal of the American …, 2017 - ACS Publications
Nanotechnology-mediated antioxidative therapy is emerging as a novel strategy for treating
a myriad of important diseases through scavenging excessive reactive oxygen and nitrogen …

Apoptosis and acute brain ischemia in ischemic stroke

D Radak, N Katsiki, I Resanovic… - Current vascular …, 2017 - ingentaconnect.com
Apoptosis may contribute to a significant proportion of neuron death following acute brain
ischemia (ABI), but the underlying mechanisms are still not fully understood. Brain ischemia …

Ischemic cell death in brain neurons

P Lipton - Physiological reviews, 1999 - journals.physiology.org
This review is directed at understanding how neuronal death occurs in two distinct insults,
global ischemia and focal ischemia. These are the two principal rodent models for human …

Apoptotic mechanisms after cerebral ischemia

BRS Broughton, DC Reutens, CG Sobey - Stroke, 2009 - Am Heart Assoc
Background and Purpose—Traditionally, cell death after cerebral ischemia was considered
to be exclusively necrotic in nature, but research over the past decade has revealed that …

Reactive oxygen radicals in signaling and damage in the ischemic brain

PH Chan - Journal of Cerebral Blood Flow & Metabolism, 2001 - journals.sagepub.com
Reactive oxygen species have been implicated in brain injury after ischemic stroke. These
oxidants can react and damage the cellular macromolecules by virtue of the reactivity that …

Apoptosis in neurodegenerative disorders

MP Mattson - Nature reviews Molecular cell biology, 2000 - nature.com
Neuronal death underlies the symptoms of many human neurological disorders, including
Alzheimer's, Parkinson's and Huntington's diseases, stroke, and amyotrophic lateral …

Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction

RS Hotchkiss, PE Swanson, BD Freeman… - Critical care …, 1999 - journals.lww.com
Objectives The purpose of this study was to determine whether apoptosis is a major
mechanism of cell death in patients with sepsis. The activities of caspase-3 and the …

[HTML][HTML] Mitochondria, oxidative metabolism and cell death in stroke

NR Sims, H Muyderman - Biochimica et Biophysica Acta (BBA)-Molecular …, 2010 - Elsevier
Stroke most commonly results from occlusion of a major artery in the brain and typically
leads to the death of all cells within the affected tissue. Mitochondria are centrally involved in …