Regulated cell death is a vital and dynamic process in multicellular organisms that maintains
tissue homeostasis and eliminates potentially dangerous cells. Apoptosis, one of the better …

Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

Nanotechnology-mediated antioxidative therapy is emerging as a novel strategy for treating
a myriad of important diseases through scavenging excessive reactive oxygen and nitrogen …

Apoptosis may contribute to a significant proportion of neuron death following acute brain
ischemia (ABI), but the underlying mechanisms are still not fully understood. Brain ischemia …

Background and Purpose—Traditionally, cell death after cerebral ischemia was considered
to be exclusively necrotic in nature, but research over the past decade has revealed that …

This review is directed at understanding how neuronal death occurs in two distinct insults,
global ischemia and focal ischemia. These are the two principal rodent models for human …

Stroke most commonly results from occlusion of a major artery in the brain and typically
leads to the death of all cells within the affected tissue. Mitochondria are centrally involved in …

Reactive oxygen species have been implicated in brain injury after ischemic stroke. These
oxidants can react and damage the cellular macromolecules by virtue of the reactivity that …

Neuronal death underlies the symptoms of many human neurological disorders, including
Alzheimer's, Parkinson's and Huntington's diseases, stroke, and amyotrophic lateral …

Neuronal apoptosis sculpts the developing brain and has a potentially important role in
neurodegenerative diseases. The principal molecular components of the apoptosis …