[HTML][HTML] Mitochondrial transplantation therapy for ischemia reperfusion injury: a systematic review of animal and human studies

K Hayashida, R Takegawa, M Shoaib, T Aoki… - Journal of Translational …, 2021 - Springer
Background Mitochondria are essential organelles that provide energy for cellular functions,
participate in cellular signaling and growth, and facilitate cell death. Based on their …

Therapeutic applications of mitochondrial transplantation

O Ulger, GB Kubat - Biochimie, 2022 - Elsevier
This review aims to make a framework of exogenous healthy mitochondrial transplantation
and to assemble present information for improving new therapeutic applications in a variety …

Salidroside ameliorates mitochondria‐dependent neuronal apoptosis after spinal cord ischemia‐reperfusion injury partially through inhibiting oxidative stress and …

C Gu, L Li, Y Huang, D Qian, W Liu… - Oxidative medicine …, 2020 - Wiley Online Library
Ischemia‐reperfusion injury is the second most common injury of the spinal cord and has the
risk of neurological dysfunction and paralysis, which can seriously affect patient quality of …

[HTML][HTML] Exogenous mitochondrial transplantation improves survival and neurological outcomes after resuscitation from cardiac arrest

K Hayashida, R Takegawa, Y Endo, T Yin… - BMC medicine, 2023 - Springer
Abstract Background Mitochondrial transplantation (MTx) is an emerging but poorly
understood technology with the potential to mitigate severe ischemia–reperfusion injuries …

Mesenchymal stem cells-derived mitochondria transplantation mitigates I/R-induced injury, abolishes I/R-induced apoptosis, and restores motor function in acute …

Z Pourmohammadi-Bejarpasi, AM Roushandeh… - Brain Research …, 2020 - Elsevier
Acute ischemia stroke (AIS) is one of the leading causes of mortality and disability
worldwide, and its neurological impacts are devastating and permanent. There is no efficient …

Prospects of mitochondrial transplantation in clinical medicine: Aspirations and challenges

S Hosseinian, PA Pour, A Kheradvar - Mitochondrion, 2022 - Elsevier
Mitochondria, known as the powerhouse of the cell, are at the center of healthy physiology
and provide cells with energy in the form of ATP. These unique organelles are also …

[HTML][HTML] Multifaceted roles of mitochondria in wound healing and chronic wound pathogenesis

M Hunt, M Torres, E Bachar-Wikström… - Frontiers in Cell and …, 2023 - frontiersin.org
Mitochondria are intracellular organelles that play a critical role in numerous cellular
processes including the regulation of metabolism, cellular stress response, and cell fate …

Mitochondrial transplantation protects against sepsis-induced myocardial dysfunction by modulating mitochondrial biogenesis and fission/fusion and inflammatory …

B Mokhtari, M Hamidi, R Badalzadeh… - Molecular Biology …, 2023 - Springer
Background Sepsis-induced myocardial dysfunction is associated with worse clinical
outcomes and high mortality, but no effective therapeutic intervention has been explored …

[HTML][HTML] Targeted transplantation of engineered mitochondrial compound promotes functional recovery after spinal cord injury by enhancing macrophage …

J Xu, C Shi, F Yuan, Y Ding, Y Xie, Y Liu, F Zhu, H Lu… - Bioactive Materials, 2024 - Elsevier
Mitochondria are crucial in sustaining and orchestrating cellular functions. Capitalizing on
this, we explored mitochondrial transplantation as an innovative therapeutic strategy for …

[HTML][HTML] Mitochondrial transplantation in mitochondrial medicine: current challenges and future perspectives

M D'Amato, F Morra, I Di Meo, V Tiranti - International journal of molecular …, 2023 - mdpi.com
Mitochondrial diseases (MDs) are inherited genetic conditions characterized by pathogenic
mutations in nuclear DNA (nDNA) or mitochondrial DNA (mtDNA). Current therapies are still …