The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …

Abstract Poly (ADP-ribose) polymerase-1 (PARP-1), also referred to as ADP-
ribosyltransferase Diphtheria toxin-like 1 (ARTD1), is an abundant nuclear protein that plays …

High salt is positively associated with the risk of many diseases. However, little is known
about the mechanisms. Here we showed that high salt increased proinflammatory …

Poly (ADP-ribosyl) ation (PARylation) is an essential post-translational modification
catalyzed by poly (ADP-ribose) polymerase (PARP) enzymes. Poly (ADP-ribose) …

ADP‐ribosylation is the addition of one or more (up to some hundreds) ADP‐ribose moieties
to acceptor proteins. There are two major families of enzymes that catalyse this reaction …

Activation and subsequent differentiation of T cells following antigenic stimulation are
triggered by highly coordinated signaling events that lead to instilling cells with a discrete …

Asthma and Chronic Obstructive Pulmonary Disease (COPD) are chronic obstructive
respiratory diseases characterized by airway obstruction, inflammation, and remodeling …

Abstract Poly (ADP-ribose) polymerases (PARPs or ARTDs), originally described as DNA
repair factors, have metabolic regulatory roles. PARP1, PARP2, PARP7, PARP10, and …

PARP enzymes influence the immune system at several key points and thus modulate
inflammatory diseases. PARP enzymes affect immune cell maturation and differentiation and …

Aberrant activation of CD4 TH 2 cells and excessive production of TH 2 cytokines such as IL-
4 and IL-13 have been implicated in the pathogenesis of allergic diseases. Generally, IL-4 …