Inside the human cancer tyrosine phosphatome

SG Julien, N Dubé, S Hardy, ML Tremblay - Nature Reviews Cancer, 2011 - nature.com
Members of the protein tyrosine phosphatase (Ptp) family dephosphorylate target proteins
and counter the activities of protein tyrosine kinases that are involved in cellular …

CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells

ML Hermiston, J Zikherman, JW Zhu - Immunological reviews, 2009 - Wiley Online Library
Reciprocal regulation of tyrosine phosphorylation by protein tyrosine kinases (PTKs) and
protein tyrosine phosphatases (PTPs) is central to normal immune cell function. Disruption of …

VE-PTP controls blood vessel development by balancing Tie-2 activity

M Winderlich, L Keller, G Cagna, A Broermann… - Journal of Cell …, 2009 - rupress.org
Vascular endothelial protein tyrosine phosphatase (VE-PTP) is an endothelial-specific
receptor-type tyrosine phosphatase that associates with Tie-2 and VE-cadherin. VE-PTP …

Targeting protein tyrosine phosphatases for anticancer drug discovery

LM Scott, HR Lawrence, SM Sebti… - Current …, 2010 - ingentaconnect.com
Protein tyrosine phosphatases (PTPs) are a diverse family of enzymes encoded by 107
genes in the human genome. Together with protein tyrosine kinases (PTKs), PTPs regulate …

Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling

JW Zhu, T Brdicka, TR Katsumoto, J Lin, A Weiss - Immunity, 2008 - cell.com
The receptor-type protein tyrosine phosphatase (RPTP) CD148 is thought to have an
inhibitory function in signaling and proliferation in nonhematopoietic cells. However, its role …

Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis

WPD Hendricks, V Zismann, K Sivaprakasam… - PLoS …, 2018 - journals.plos.org
Canine malignant melanoma, a significant cause of mortality in domestic dogs, is a powerful
comparative model for human melanoma, but little is known about its genetic etiology. We …

[HTML][HTML] Protein tyrosine phosphatase variants in human hereditary disorders and disease susceptibilities

WJAJ Hendriks, R Pulido - Biochimica et Biophysica Acta (BBA)-Molecular …, 2013 - Elsevier
Reversible tyrosine phosphorylation of proteins is a key regulatory mechanism to steer
normal development and physiological functioning of multicellular organisms …

Genetic alterations of protein tyrosine phosphatases in human cancers

S Zhao, D Sedwick, Z Wang - Oncogene, 2015 - nature.com
Protein tyrosine phosphatases (PTPs) are enzymes that remove phosphate from tyrosine
residues in proteins. Recent whole-exome sequencing of human cancer genomes reveals …

Shed syndecan-2 inhibits angiogenesis

G De Rossi, AR Evans, E Kay, A Woodfin… - Journal of cell …, 2014 - journals.biologists.com
Angiogenesis is essential for the development of a normal vasculature, tissue repair and
reproduction, and also has roles in the progression of diseases such as cancer and …

Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148

JR Whiteford, X Xian, C Chaussade… - Molecular biology of …, 2011 - Am Soc Cell Biol
Syndecan-2 is a heparan sulfate proteoglycan that has a cell adhesion regulatory domain
contained within its extracellular core protein. Cell adhesion to the syndecan-2 extracellular …