Long‐term plasticity in the hippocampus: maintaining within and 'tagging'between synapses
Synapses between neurons are malleable biochemical structures, strengthening and
diminishing over time dependent on the type of information they receive. This phenomenon …
diminishing over time dependent on the type of information they receive. This phenomenon …
[HTML][HTML] CA2 beyond social memory: Evidence for a fundamental role in hippocampal information processing
Hippocampal region CA2 has received increased attention due to its importance in social
recognition memory. While its specific function remains to be identified, there are indications …
recognition memory. While its specific function remains to be identified, there are indications …
Hippocampal CA2 sharp-wave ripples reactivate and promote social memory
The consolidation of spatial memory depends on the reactivation ('replay') of hippocampal
place cells that were active during recent behaviour. Such reactivation is observed during …
place cells that were active during recent behaviour. Such reactivation is observed during …
Coding of social novelty in the hippocampal CA2 region and its disruption and rescue in a 22q11. 2 microdeletion mouse model
The hippocampal CA2 region is essential for social memory. To determine whether CA2
activity encodes social interactions, we recorded extracellularly from CA2 pyramidal neurons …
activity encodes social interactions, we recorded extracellularly from CA2 pyramidal neurons …
Activation of the CA2-ventral CA1 pathway reverses social discrimination dysfunction in Shank3B knockout mice
Mutation or deletion of the SHANK3 gene, which encodes a synaptic scaffolding protein, is
linked to autism spectrum disorder and Phelan-McDermid syndrome, conditions associated …
linked to autism spectrum disorder and Phelan-McDermid syndrome, conditions associated …
Perineuronal net degradation rescues CA2 plasticity in a mouse model of Rett syndrome
KE Carstens, DJ Lustberg… - The Journal of …, 2021 - Am Soc Clin Investig
Perineuronal nets (PNNs), a specialized form of extracellular matrix, are abnormal in the
brains of people with Rett syndrome (RTT). We previously reported that PNNs function to …
brains of people with Rett syndrome (RTT). We previously reported that PNNs function to …
Hippocampal subregions express distinct dendritic transcriptomes that reveal differences in mitochondrial function in CA2
RNA localization is one mechanism neurons use to spatially and temporally regulate gene
expression at synapses. Here, we test the hypothesis that cells exhibiting distinct forms of …
expression at synapses. Here, we test the hypothesis that cells exhibiting distinct forms of …
CA2 orchestrates hippocampal network dynamics
A Oliva, A Fernandez‐Ruiz, LA Karaba - Hippocampus, 2023 - Wiley Online Library
The hippocampus is composed of various subregions: CA1, CA2, CA3, and the dentate
gyrus (DG). Despite the abundant hippocampal research literature, until recently, CA2 …
gyrus (DG). Despite the abundant hippocampal research literature, until recently, CA2 …
[HTML][HTML] Newborn mice form lasting CA2-dependent memories of their mothers
BJ Laham, EJ Diethorn, E Gould - Cell Reports, 2021 - cell.com
Some of the most enduring social connections begin when infants first recognize their
caregivers, memories that form the basis of many family relationships. It remains unknown …
caregivers, memories that form the basis of many family relationships. It remains unknown …
Enkephalin release from VIP interneurons in the hippocampal CA2/3a region mediates heterosynaptic plasticity and social memory
The hippocampus contains a diverse array of inhibitory interneurons that gate information
flow through local cortico-hippocampal circuits to regulate memory storage. Although most …
flow through local cortico-hippocampal circuits to regulate memory storage. Although most …