Over the last 10 years there has been an explosion of information about the molecular
biology of cancer. A challenge in oncology is to translate this information into advances in …

Prostate cancer is a major cause of cancer‐related deaths among men worldwide. In
addition to genomic alterations, epigenetic alterations accumulated in prostate cancer have …

After briefly reviewing the nature of DNA methylation, its general role in cancer and the tools
available to interrogate it, we consider the literature surrounding DNA methylation as …

Advanced prostate cancers are known to acquire not only invasive capabilities but also
significant resistance to chemotherapy-induced apoptosis. To understand how microRNAs …

Androgen receptor signaling plays a critical role in prostate cancer pathogenesis. Yet, the
regulation of androgen receptor signaling remains elusive. Even with stringent androgen …

The term “epigenetics” refers to modifications in gene expression caused by heritable, but
potentially reversible, changes in DNA methylation and chromatin structure. Given the fact …

A biomarker is a molecular target analyzed in a qualitative or quantitative manner to detect
and diagnose the presence of a disease, to predict the outcome and the response to a …

BACKGROUND Prostate cancer is the most common cancer diagnosis in men and a leading
cause of death. Improvements in disease management would have a significant impact and …

Epigenetic alterations, including changes in DNA methylation, histone modifications and
nucleosome remodeling, result in abnormal gene expression patterns that contribute to …

Promoter CpG island hypermethylation is an important carcinogenic event in prostate
adenocarcinoma. Regardless of tissue type, human cancers have in common both focal …