Abstract The epithelial Na+ channel (ENaC) transports Na+ across tight epithelia, including
the distal nephron. Different paradigms of ENaC regulation include extrinsic and intrinsic …

Amiloride-sensitive epithelial sodium channels (ENaC) play an important role in lung
sodium transport. Sodium transport is closely regulated to maintain an appropriate fluid layer …

We recently found that the metabolic sensor AMP-activated kinase (AMPK) inhibits the
epithelial Na+ channel (ENaC) through decreased plasma membrane ENaC expression, an …

The epithelial Na+ channel (ENaC) regulates epithelial salt and water reabsorption,
processes that require significant expenditure of cellular energy. To test whether the …

Preterm infants frequently suffer from pulmonary complications due to a physiological and
structural lung immaturity resulting in significant morbidity and mortality. Novel in vitro and in …

Respiratory distress syndrome (RDS) is the most frequent pulmonary complication in
preterm infants. RDS incidence differs between genders, which has been called the male …

Abstract Background Mesenchymal stem cells (MSCs) were shown to harbor therapeutic
potential in models of respiratory diseases, such as bronchopulmonary dysplasia (BPD), the …

As earlier studies have focused on the role of nucleotides such as ATP in regulating
transport-protein activities, the regulation of membrane transport by AMPK represents a …

The epithelial Na+ channel (ENaC) and acid-sensitive ion channel (ASIC) branches of the
ENaC/degenerin superfamily of cation channels have drawn increasing attention as …

The alveolar surface of the lung is lined by alveolar type 1 (AT1) and type 2 (AT2) cells.
Using single channel patch clamp analysis in lung slice preparations, we are able to …