Extensive studies during the last 30 years have led to considerable understanding of cellular
and molecular control of hemoglobin switching. Cell biology studies in the 1970s defined the …

Increased levels of fetal hemoglobin (HbF) can ameliorate the clinical course of inherited
disorders of β‐globin gene expression, such as β thalassemia and sickle cell anemia. In a …

The ENCODE Project has generated a wealth of experimental information mapping diverse
chromatin properties in several human cell lines. Although each such data track is …

In the new edition of this successful and authoritative book, the thalassaemias are reviewed
in detail with respect to their clinical features, cellular pathology, molecular genetics …

Gene activation requires chromatin remodeling complexes, which hyperacetylate histones
and enable factor access; however, the targeting mechanisms leading to the establishment …

Background An improved understanding of the regulation of the fetal hemoglobin genes
holds promise for the development of targeted therapeutic approaches for fetal hemoglobin …

We have previously described the development of oncoretrovirus vectors for human γ-globin
using a truncated β-globin promoter, modified γ-globin cassette, and α-globin enhancer …

Ex vivo cellular system that accurately replicates sickle cell disease and β-thalassemia
characteristics is a highly sought-after goal in the field of erythroid biology. In this study, we …

Transcription of the human β-like globin genes in erythroid cells is regulated by the far-
upstream locus control region (LCR). In an attempt to define the 5′ border of the LCR, we …

Although the domain organization of the eukaryotic genome has been repeatedly discussed
in the literature (Goldman, 1988; Razin et al., 1993; Razin, 1996; Geyer, 1997; Dillon and …