Obesity and ageing place a tremendous strain on the global healthcare system. Age-related
sarcopenia is characterized by decreased muscular strength, decreased muscle quantity …

Sarcopenia, an age-associated decline in skeletal muscle mass coupled with functional
deterioration, may be exacerbated by obesity leading to higher disability, frailty, morbidity …

Irisin is a myokine that leads to increased energy expenditure by stimulating the'browning'of
white adipose tissue. In the first description of this hormone, increased levels of circulating …

Physical exercise has beneficial effects on metabolic diseases, and a combined therapeutic
regimen of regular exercise and pharmaceutical treatment is often recommended for their …

In 2002, a transmembrane protein—now known as FNDC5—was discovered and shown to
be expressed in skeletal muscle, heart, and brain. It was virtually ignored for 10 years, until a …

The prevalence of sarcopenic obesity is increasing worldwide, particularly amongst aging
populations. Insulin resistance is the core mechanism of sarcopenic obesity and is also …

Population aging and the obesity epidemic are important global public health problems that
pose an unprecedented threat to the physical and mental health of the elderly and health …

Exercise is an effective strategy for preventing and treating obesity and its related
cardiometabolic disorders, resulting in significant loss of body fat mass, white adipose tissue …

Introduction Irisin is a myokine/adipokine induced by the exercise in mice and humans,
which is proposed to induce “browning” of white adipose tissue, its primary target, thus …

Increased glucose production and reduced hepatic glycogen storage contribute to metabolic
abnormalities in diabetes. Irisin, a newly identified myokine, induces the browning of white …