Liquid chromatography-mass spectrometry (LC-MS) is now a routine technique with the
development of electrospray ionisation (ESI) providing a simple and robust interface. It can …

Recent advancements in the sensitivity of chemical instrumentation have led to increased
interest in the use of microsamples for translational and biomedical research. Paper …

Handling of data below the lower limit of quantification (LLOQ), below the limit of
quantification (BLOQ) in population pharmacokinetic (PopPK) analyses is important for …

LC–MS/MS is an increasingly important tool in therapeutic drug monitoring as it offers
increased sensitivity and specificity compared to other methods, and may be the only viable …

Clinical pharmacokinetic studies of antiretrovirals require accurate and precise
measurement of plasma drug concentrations. Here we describe a simple, fast and sensitive …

Raltegravir (RAL), maraviroc (MVC), darunavir (DRV), and etravirine (ETV) are new
antiretroviral agents with significant potential for drug interactions. This work describes a …

A bioanalytical method for the determination of most commonly prescribed protease
inhibitors (atazanavir, darunavir, lopinavir and ritonavir) and non-nucleoside reverse …

A new method using high performance liquid chromatography coupled with electrospray
mass spectrometry (HPLC–MS) was developed and validated, for the quantification of …

This review is a Part II of the series aiming to provide comprehensive overview of currently
used antiviral drugs and to show modern approaches to their analysis. While in the Part I …

A new method using high-performance liquid chromatography coupled with photo diode
array detection was developed and validated for the quantification of plasma concentrations …