Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

Pathophysiology and therapeutic approaches for spinal cord injury

R Lima, A Monteiro, AJ Salgado, S Monteiro… - International Journal of …, 2022 - mdpi.com
Spinal cord injury (SCI) is a disabling condition that disrupts motor, sensory, and autonomic
functions. Despite extensive research in the last decades, SCI continues to be a global …

Schwann cell-derived exosomes and methylprednisolone composite patch for spinal cord injury repair

B Zhu, G Gu, J Ren, X Song, J Li, C Wang, W Zhang… - ACS …, 2023 - ACS Publications
Spinal cord injury (SCI) can cause permanent loss of sensory and motor function, and there
is no effective clinical treatment, to date. Due to the complex pathological process involved …

Schwann cell-derived exosomes containing MFG-E8 modify macrophage/microglial polarization for attenuating inflammation via the SOCS3/STAT3 pathway after …

J Ren, B Zhu, G Gu, W Zhang, J Li, H Wang… - Cell death & …, 2023 - nature.com
Macrophage/microglia polarization acts as an important part in regulating inflammatory
responses in spinal cord injury (SCI). However, the regulation of inflammation of Schwann …

[HTML][HTML] 3, 4-Dimethoxychalcone, a caloric restriction mimetic, enhances TFEB-mediated autophagy and alleviates pyroptosis and necroptosis after spinal cord injury

H Zhang, W Ni, G Yu, Y Geng, J Lou, J Qi, Y Chen… - Theranostics, 2023 - ncbi.nlm.nih.gov
Background: Caloric restriction mimetics (CRMs) mimic the favourable effects of caloric
restriction (CR) and have been shown to have therapeutic effects in neuroinflammatory …

The exosome-mediated PI3K/Akt/mTOR signaling pathway in neurological diseases

A Iranpanah, L Kooshki, SZ Moradi, L Saso, S Fakhri… - Pharmaceutics, 2023 - mdpi.com
As major public health concerns associated with a rapidly growing aging population,
neurodegenerative diseases (NDDs) and neurological diseases are important causes of …

Astroglial Cells: Emerging Therapeutic Targets in the Management of Traumatic Brain Injury

W Czyżewski, M Mazurek, L Sakwa, M Szymoniuk… - Cells, 2024 - mdpi.com
Traumatic Brain Injury (TBI) represents a significant health concern, necessitating advanced
therapeutic interventions. This detailed review explores the critical roles of astrocytes, key …

Exosomes combined with biomaterials in the treatment of spinal cord injury

X Zhang, W Jiang, Y Lu, T Mao, Y Gu, D Ju… - … in Bioengineering and …, 2023 - frontiersin.org
Spinal cord injury (SCI) is a serious and disabling disease with a high mortality rate. It often
leads to complete or partial sensory and motor dysfunction and is accompanied by a series …

Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization

H Zhang, Y Chen, F Li, C Wu, W Cai, H Ye, H Su… - Journal of …, 2023 - Springer
Spinal cord injury (SCI) is a devastating injury that may result in permanent motor
impairment. The active ingredients of medications are unable to reach the affected area due …

Schwann cell-derived exosomal vesicles: a promising therapy for the injured spinal cord

M Ghosh, DD Pearse - International Journal of Molecular Sciences, 2023 - mdpi.com
Exosomes are nanoscale-sized membrane vesicles released by cells into their extracellular
milieu. Within these nanovesicles reside a multitude of bioactive molecules, which …