MSC based therapies—new perspectives for the injured lung

J Behnke, S Kremer, T Shahzad, CM Chao… - Journal of clinical …, 2020 - mdpi.com
Chronic lung diseases pose a tremendous global burden. At least one in four people suffer
from severe pulmonary sequelae over the course of a lifetime. Despite substantial …

[HTML][HTML] Regulatory immune cells in idiopathic pulmonary fibrosis: friends or foes?

C van Geffen, A Deißler, M Quante, H Renz… - Frontiers in …, 2021 - frontiersin.org
The immune system is receiving increasing attention for interstitial lung diseases, as
knowledge on its role in fibrosis development and response to therapies is expanding …

Clinical features of COVID‐19 convalescent patients with re‐positive nucleic acid detection

H Zhu, L Fu, Y Jin, J Shao, S Zhang… - Journal of clinical …, 2020 - Wiley Online Library
Abstract Background Coronavirus disease 2019 (COVID‐19) is a pandemic that has rapidly
spread worldwide. Increasingly, confirmed patients being discharged according to the …

Impairment of the NKT–STAT1–CXCL9 axis contributes to vessel fibrosis in pulmonary hypertension caused by lung fibrosis

K Jandl, LM Marsh, AC Mutgan, S Crnkovic… - American Journal of …, 2022 - atsjournals.org
Rationale: Pulmonary hypertension (PH) is a common, severe comorbidity in interstitial lung
diseases such as pulmonary fibrosis (PF), and it has limited treatment options. Excessive …

[HTML][HTML] The use of human mesenchymal stem cells as therapeutic agents for the in vivo treatment of immune-related diseases: a systematic review

A Leyendecker Jr, CCG Pinheiro, MT Amano… - Frontiers in …, 2018 - frontiersin.org
Background: One of the greatest challenges for medicine is to find a safe and effective
treatment for immune-related diseases. However, due to the low efficacy of the treatment …

Chaotic activation of developmental signalling pathways drives idiopathic pulmonary fibrosis

A Froidure, E Marchal-Duval… - European …, 2020 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is characterised by an important remodelling of lung
parenchyma. Current evidence indicates that the disease is triggered by alveolar epithelium …

[HTML][HTML] Mesenchymal stem cells in idiopathic pulmonary fibrosis

X Li, S Yue, Z Luo - Oncotarget, 2017 - ncbi.nlm.nih.gov
Idiopathic pulmonary fibrosis (IPF) is a major cause of respiratory failure in critically ill
patients and common outcome of various lung interstitial diseases. Its mortality remains …

Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles in COVID-19-induced ARDS: Mechanisms of action, research progress, challenges …

S Moradinasab, A Pourbagheri-Sigaroodi… - International …, 2021 - Elsevier
In late 2019, a novel coronavirus (SARS-CoV-2) emerged in Wuhan city, Hubei province,
China. Rapidly escalated into a worldwide pandemic, it has caused an unprecedented and …

Current research and use of mesenchymal stem cells in the therapy of autoimmune diseases

Y Chen, Q Yu, Y Hu, Y Shi - Current stem cell research & …, 2019 - ingentaconnect.com
Mesenchymal Stem Cells (MSCs) represent a heterogeneous group of self-renewal,
multipotent non-hematopoietic stem cells, which display profound immunomodulatory …

Effects of mesenchymal stromal cell-derived extracellular vesicles in lung diseases: current status and future perspectives

H Guo, Y Su, F Deng - Stem cell reviews and reports, 2021 - Springer
Mesenchymal stromal cells (MSCs) as a kind of pluripotent adult stem cell have shown great
therapeutic potential in relation to many diseases in anti-inflammation and regeneration. The …