Acute lung injury (ALI) carries a mortality rate of~ 50% and is a hot topic in the world of
critical illness research. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a critical …

Background Colorectal cancer (CRC) is one of the most common malignant tumors in the
world. Ferroptosis is a newly defined form of cell death, distinguished by different …

Background: Sepsis-induced cardiomyopathy (SIC) is a severe myocardial dysfunction
secondary to septicemia. It is a major concern owing to the high mortality and morbidity …

Aims It was aimed to investigate the thioredoxin reductase 1 (TrxR1)-targeted anticancer
effect of vulpinic (VA) and lecanoric (LA) acids, which are lichen secondary metabolites, on …

Abstract Di (2-ethylhexyl) phthalate (DEHP) is a widely artificial persistent organic pollutant,
the contamination of which infiltrates daily human life from many aspects, imperceptibly …

Breast cancer represents one of the most frequently encountered cancer types among
women worldwide. Thioredoxin reductase 1 (TrxR1) is a therapeutic target for breast cancer …

Scope Excessive iron contributes to oxidative damage and cognitive decline in Alzheimer's
disease. Sesamol, a compound in sesame oil that exhibits both anti‐inflammatory and …

Abstract Thioredoxin reductase 1 (TrxR1) has emerged as an important target for anticancer
drug development due to its overexpression in many human tumors including breast cancer …

The progression of heart failure (HF) is complex and involves multiple regulatory pathways.
Iron ions play a crucial supportive role as a cofactor for important proteins such as …

Cadmium (Cd) is a toxic and carcinogenic heavy metal pollutant leading to serious damage
in various organs. Ferroptosis and necrosis as inflammation-related cell death are involved …